Strauss E - Search Results

1

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.

Spry C, Barnard L, Kok M, Powell AK, Mahesh D, Tjhin ET, Saliba KJ, Strauss E, de Villiers M. Spry C, et al. Among authors: strauss e. ACS Infect Dis. 2020 Jul 10;6(7):1844-1854. doi: 10.1021/acsinfecdis.0c00075. Epub 2020 May 28. ACS Infect Dis. 2020. PMID: 32375471

2

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization.

van Wyk M, Strauss E. van Wyk M, et al. Among authors: strauss e. Org Biomol Chem. 2008 Dec 7;6(23):4348-55. doi: 10.1039/b811086g. Epub 2008 Oct 17. Org Biomol Chem. 2008. PMID: 19005594

3

Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.

Spry C, van Schalkwyk DA, Strauss E, Saliba KJ. Spry C, et al. Among authors: strauss e. Infect Disord Drug Targets. 2010 Jun;10(3):200-16. doi: 10.2174/187152610791163390. Infect Disord Drug Targets. 2010. PMID: 20334619 Review.

4

The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.

van der Westhuyzen R, Hammons JC, Meier JL, Dahesh S, Moolman WJ, Pelly SC, Nizet V, Burkart MD, Strauss E. van der Westhuyzen R, et al. Among authors: strauss e. Chem Biol. 2012 May 25;19(5):559-71. doi: 10.1016/j.chembiol.2012.03.013. Chem Biol. 2012. PMID: 22633408 Free PMC article.

5

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, Strauss E, Saliba KJ. Spry C, et al. Among authors: strauss e. PLoS One. 2013;8(2):e54974. doi: 10.1371/journal.pone.0054974. Epub 2013 Feb 6. PLoS One. 2013. PMID: 23405100 Free PMC article.

6

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices.

Spry C, Saliba KJ, Strauss E. Spry C, et al. Among authors: strauss e. Anal Biochem. 2014 Apr 15;451:76-8. doi: 10.1016/j.ab.2013.12.010. Epub 2013 Dec 12. Anal Biochem. 2014. PMID: 24333332

7

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

de Villiers M, Macuamule C, Spry C, Hyun YM, Strauss E, Saliba KJ. de Villiers M, et al. Among authors: strauss e. ACS Med Chem Lett. 2013 Jun 17;4(8):784-9. doi: 10.1021/ml400180d. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900746 Free PMC article.

8

Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development.

Moolman WJ, de Villiers M, Strauss E. Moolman WJ, et al. Among authors: strauss e. Biochem Soc Trans. 2014 Aug;42(4):1080-6. doi: 10.1042/BST20140131. Biochem Soc Trans. 2014. PMID: 25110006 Review.

9

Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.

de Villiers M, Barnard L, Koekemoer L, Snoep JL, Strauss E. de Villiers M, et al. Among authors: strauss e. FEBS J. 2014 Oct;281(20):4731-53. doi: 10.1111/febs.13013. Epub 2014 Oct 7. FEBS J. 2014. PMID: 25156889 Free article.

10

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Macuamule CJ, Tjhin ET, Jana CE, Barnard L, Koekemoer L, de Villiers M, Saliba KJ, Strauss E. Macuamule CJ, et al. Among authors: strauss e. Antimicrob Agents Chemother. 2015;59(6):3666-8. doi: 10.1128/AAC.04970-14. Epub 2015 Apr 6. Antimicrob Agents Chemother. 2015. PMID: 25845876 Free PMC article.

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