Tjhin ET - Search Results

1

Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.

Spry C, Barnard L, Kok M, Powell AK, Mahesh D, Tjhin ET, Saliba KJ, Strauss E, de Villiers M. Spry C, et al. Among authors: tjhin et. ACS Infect Dis. 2020 Jul 10;6(7):1844-1854. doi: 10.1021/acsinfecdis.0c00075. Epub 2020 May 28. ACS Infect Dis. 2020. PMID: 32375471

2

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity.

Macuamule CJ, Tjhin ET, Jana CE, Barnard L, Koekemoer L, de Villiers M, Saliba KJ, Strauss E. Macuamule CJ, et al. Among authors: tjhin et. Antimicrob Agents Chemother. 2015;59(6):3666-8. doi: 10.1128/AAC.04970-14. Epub 2015 Apr 6. Antimicrob Agents Chemother. 2015. PMID: 25845876 Free PMC article.

3

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ. Tjhin ET, et al. PLoS Pathog. 2018 Apr 3;14(4):e1006918. doi: 10.1371/journal.ppat.1006918. eCollection 2018 Apr. PLoS Pathog. 2018. PMID: 29614109 Free PMC article.

4

Structure-Activity Relationships of Antiplasmodial Pantothenamide Analogues Reveal a New Way by Which Triazoles Mimic Amide Bonds.

Guan J, Tjhin ET, Howieson VM, Kittikool T, Spry C, Saliba KJ, Auclair K. Guan J, et al. Among authors: tjhin et. ChemMedChem. 2018 Dec 20;13(24):2677-2683. doi: 10.1002/cmdc.201800327. Epub 2018 Nov 29. ChemMedChem. 2018. PMID: 30370998

5

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

Domingo R, van der Westhuyzen R, Hamann AR, Mostert KJ, Barnard L, Paquet T, Tjhin ET, Saliba KJ, van Otterlo WAL, Strauss E. Domingo R, et al. Among authors: tjhin et. Medchemcomm. 2019 Oct 17;10(12):2118-2125. doi: 10.1039/c9md00312f. eCollection 2019 Dec 1. Medchemcomm. 2019. PMID: 32206243 Free PMC article.

6

Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides.

Guan J, Spry C, Tjhin ET, Yang P, Kittikool T, Howieson VM, Ling H, Starrs L, Duncan D, Burgio G, Saliba KJ, Auclair K. Guan J, et al. Among authors: tjhin et. J Med Chem. 2021 Apr 22;64(8):4478-4497. doi: 10.1021/acs.jmedchem.0c01755. Epub 2021 Apr 1. J Med Chem. 2021. PMID: 33792339

7

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.

Fisher GM, Cobbold SA, Jezewski A, Carpenter EF, Arnold M, Cowell AN, Tjhin ET, Saliba KJ, Skinner-Adams TS, Lee MCS, Odom John A, Winzeler EA, McConville MJ, Poulsen SA, Andrews KT. Fisher GM, et al. Among authors: tjhin et. mBio. 2020 Dec 8;11(6):e02842-20. doi: 10.1128/mBio.02842-20. mBio. 2020. PMID: 33293381 Free PMC article.

8

A novel heteromeric pantothenate kinase complex in apicomplexan parasites.

Tjhin ET, Howieson VM, Spry C, van Dooren GG, Saliba KJ. Tjhin ET, et al. PLoS Pathog. 2021 Jul 29;17(7):e1009797. doi: 10.1371/journal.ppat.1009797. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34324601 Free PMC article.

9

Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis.

Tjhin ET, Staines HM, van Schalkwyk DA, Krishna S, Saliba KJ. Tjhin ET, et al. FEBS Lett. 2013 Oct 1;587(19):3182-7. doi: 10.1016/j.febslet.2013.07.052. Epub 2013 Aug 13. FEBS Lett. 2013. PMID: 23954294 Free article.

10

Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii.

Rajendran E, Clark M, Goulart C, Steinhöfel B, Tjhin ET, Gross S, Smith NC, Kirk K, van Dooren GG. Rajendran E, et al. Among authors: tjhin et. PLoS Pathog. 2021 Aug 5;17(8):e1009816. doi: 10.1371/journal.ppat.1009816. eCollection 2021 Aug. PLoS Pathog. 2021. PMID: 34352043 Free PMC article.

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