Lerner RA - Search Results

1

A DNA-encoded library for the identification of natural product binders that modulate poly (ADP-ribose) polymerase 1, a validated anti-cancer target.

Li J, Li Y, Lu F, Liu L, Ji Q, Song K, Yin Q, Lerner RA, Yang G, Xu H, Ma P. Li J, et al. Among authors: lerner ra. Biochem Biophys Res Commun. 2020 Dec 3;533(2):241-248. doi: 10.1016/j.bbrc.2020.04.022. Epub 2020 May 4. Biochem Biophys Res Commun. 2020. PMID: 32381359

2

Functionality-Independent DNA Encoding of Complex Natural Products.

Ma P, Xu H, Li J, Lu F, Ma F, Wang S, Xiong H, Wang W, Buratto D, Zonta F, Wang N, Liu K, Hua T, Liu ZJ, Yang G, Lerner RA. Ma P, et al. Among authors: lerner ra. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9254-9261. doi: 10.1002/anie.201901485. Epub 2019 May 22. Angew Chem Int Ed Engl. 2019. PMID: 31020752 Review.

3

DNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives.

Ma F, Li J, Zhang S, Gu Y, Tan T, Chen W, Wang S, Ma P, Xu H, Yang G, Lerner RA. Ma F, et al. Among authors: lerner ra. Chemistry. 2021 Jun 1;27(31):8214-8220. doi: 10.1002/chem.202100850. Epub 2021 Apr 27. Chemistry. 2021. PMID: 33811386

4

DNA-Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On-DNA Suzuki, Sonogashira, and Buchwald Reactions.

Xu H, Ma F, Wang N, Hou W, Xiong H, Lu F, Li J, Wang S, Ma P, Yang G, Lerner RA. Xu H, et al. Among authors: lerner ra. Adv Sci (Weinh). 2019 Sep 30;6(23):1901551. doi: 10.1002/advs.201901551. eCollection 2019 Dec. Adv Sci (Weinh). 2019. PMID: 31832315 Free PMC article.

5

A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries.

Xu H, Gu Y, Zhang S, Xiong H, Ma F, Lu F, Ji Q, Liu L, Ma P, Hou W, Yang G, Lerner RA. Xu H, et al. Among authors: lerner ra. Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13273-13280. doi: 10.1002/anie.202003595. Epub 2020 Apr 28. Angew Chem Int Ed Engl. 2020. PMID: 32282979

6

Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products.

Xie J, Wang S, Ma P, Ma F, Li J, Wang W, Lu F, Xiong H, Gu Y, Zhang S, Xu H, Yang G, Lerner RA. Xie J, et al. Among authors: lerner ra. iScience. 2020 Jun 26;23(6):101197. doi: 10.1016/j.isci.2020.101197. Epub 2020 May 23. iScience. 2020. PMID: 32544667 Free PMC article.

7

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo.

Tao P, Kuang Y, Li Y, Li W, Gao Z, Liu L, Qiang M, Zha Z, Fan K, Ma P, Friedman JM, Yang G, Lerner RA. Tao P, et al. Among authors: lerner ra. Adv Sci (Weinh). 2020 Jul 1;7(16):2000818. doi: 10.1002/advs.202000818. eCollection 2020 Aug. Adv Sci (Weinh). 2020. PMID: 32832353 Free PMC article.

8

Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago.

Qiang M, Ma P, Li Y, Liu H, Harding A, Min C, Wang F, Liu L, Yuan M, Ji Q, Tao P, Shi X, Li Z, Li T, Wang X, Zhang Y, Wu NC, Lee CD, Zhu X, Gilbert-Jaramillo J, Zhang C, Saxena A, Huang X, Wang H, James W, Dwek RA, Wilson IA, Yang G, Lerner RA. Qiang M, et al. Among authors: lerner ra. Adv Sci (Weinh). 2022 Jan;9(1):e2102181. doi: 10.1002/advs.202102181. Epub 2021 Oct 29. Adv Sci (Weinh). 2022. PMID: 34716683 Free PMC article.

9

Reflections on DNA-encoded chemical libraries.

Lerner RA, Neri D. Lerner RA, et al. Biochem Biophys Res Commun. 2020 Jun 30;527(3):757-759. doi: 10.1016/j.bbrc.2020.04.080. Epub 2020 May 18. Biochem Biophys Res Commun. 2020. PMID: 32439178

10

Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.

Shi X, Wan Y, Wang N, Xiang J, Wang T, Yang X, Wang J, Dong X, Dong L, Yan L, Li Y, Liu L, Hou S, Zhong Z, Wilson IA, Yang B, Yang G, Lerner RA. Shi X, et al. Among authors: lerner ra. Nat Commun. 2021 May 5;12(1):2547. doi: 10.1038/s41467-021-22810-z. Nat Commun. 2021. PMID: 33953162 Free PMC article.

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