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Rare-variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associations of orphan G protein-coupled receptors.
Dershem R, Metpally RPR, Jeffreys K, Krishnamurthy S, Smelser DT, Hershfinkel M; Regeneron Genetics Center; Carey DJ, Robishaw JD, Breitwieser GE. Dershem R, et al. J Biol Chem. 2019 Nov 29;294(48):18109-18121. doi: 10.1074/jbc.RA119.009253. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628190 Free PMC article.
Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders.
Breitwieser GE, Cippitelli A, Wang Y, Pelletier O, Dershem R, Wei J, Toll L, Fakhoury B, Brunori G, Metpally R, Carey DJ; Regeneron Genetics Center; Robishaw J. Breitwieser GE, et al. Among authors: dershem r. bioRxiv [Preprint]. 2023 Jul 7:2023.07.05.547546. doi: 10.1101/2023.07.05.547546. bioRxiv. 2023. Update in: J Neurosci. 2024 May 8;44(19):e1226232024. doi: 10.1523/JNEUROSCI.1226-23.2024 PMID: 37461723 Free PMC article. Updated. Preprint.