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Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria.
Vijay R, Guthmiller JJ, Sturtz AJ, Surette FA, Rogers KJ, Sompallae RR, Li F, Pope RL, Chan JA, de Labastida Rivera F, Andrew D, Webb L, Maury WJ, Xue HH, Engwerda CR, McCarthy JS, Boyle MJ, Butler NS. Vijay R, et al. Among authors: li f. Nat Immunol. 2020 Jul;21(7):790-801. doi: 10.1038/s41590-020-0678-5. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424361 Free PMC article. Clinical Trial.
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH. Shan Q, et al. Among authors: li f. Nat Immunol. 2017 Aug;18(8):931-939. doi: 10.1038/ni.3773. Epub 2017 Jun 12. Nat Immunol. 2017. PMID: 28604718 Free PMC article.
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