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Overlapping hotspots in CDRs are critical sites for V region diversification.
Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T. Wei L, et al. Among authors: scharff md. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E728-37. doi: 10.1073/pnas.1500788112. Epub 2015 Feb 2. Proc Natl Acad Sci U S A. 2015. PMID: 25646473 Free PMC article.
Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course.
Bagnara D, Tang C, Brown JR, Kasar S, Fernandes S, Colombo M, Vergani S, Mazzarello AN, Ghiotto F, Bruno S, Morabito F, Rai KR, Kolitz JE, Barrientos JC, Allen SL, Fais F, Scharff MD, MacCarthy T, Chiorazzi N. Bagnara D, et al. Among authors: scharff md. Front Oncol. 2021 May 25;11:640731. doi: 10.3389/fonc.2021.640731. eCollection 2021. Front Oncol. 2021. PMID: 34113563 Free PMC article.
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions.
Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, Scharff MD, Chiorazzi N. Patten PE, et al. Among authors: scharff md. Blood. 2012 Dec 6;120(24):4802-11. doi: 10.1182/blood-2012-08-449744. Epub 2012 Oct 15. Blood. 2012. PMID: 23071276 Free PMC article.
263 results