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Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Bergamaschi C, Pandit H, Nagy BA, Stellas D, Jensen SM, Bear J, Cam M, Valentin A, Fox BA, Felber BK, Pavlakis GN. Bergamaschi C, et al. Among authors: nagy ba. J Immunother Cancer. 2020 May;8(1):e000599. doi: 10.1136/jitc-2020-000599. J Immunother Cancer. 2020. PMID: 32461349 Free PMC article.
Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion.
Ng SSM, Nagy BA, Jensen SM, Hu X, Alicea C, Fox BA, Felber BK, Bergamaschi C, Pavlakis GN. Ng SSM, et al. Among authors: nagy ba. Clin Cancer Res. 2017 Jun 1;23(11):2817-2830. doi: 10.1158/1078-0432.CCR-16-1808. Epub 2016 Dec 16. Clin Cancer Res. 2017. PMID: 27986749 Free PMC article.