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Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
Honorat JA, Nakatsuji Y, Shimizu M, Kinoshita M, Sumi-Akamaru H, Sasaki T, Takata K, Koda T, Namba A, Yamashita K, Sanda E, Sakaguchi M, Kumanogoh A, Shirakura T, Tamura M, Sakoda S, Mochizuki H, Okuno T. Honorat JA, et al. Among authors: shimizu m. PLoS One. 2017 Nov 6;12(11):e0187215. doi: 10.1371/journal.pone.0187215. eCollection 2017. PLoS One. 2017. PMID: 29107957 Free PMC article.
Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.
Koda T, Namba A, Nakatsuji Y, Niino M, Miyazaki Y, Sugimoto T, Kinoshita M, Takata K, Yamashita K, Shimizu M, Fukazawa T, Kumanogoh A, Mochizuki H, Okuno T. Koda T, et al. Among authors: shimizu m. PLoS One. 2018 Mar 8;13(3):e0193986. doi: 10.1371/journal.pone.0193986. eCollection 2018. PLoS One. 2018. PMID: 29518148 Free PMC article.
Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder.
Yamashita K, Kinoshita M, Miyamoto K, Namba A, Shimizu M, Koda T, Sugimoto T, Mori Y, Yoshioka Y, Nakatsuji Y, Kumanogoh A, Kusunoki S, Mochizuki H, Okuno T. Yamashita K, et al. Among authors: shimizu m. J Neuroinflammation. 2018 Apr 27;15(1):125. doi: 10.1186/s12974-018-1162-0. J Neuroinflammation. 2018. PMID: 29703264 Free PMC article.
Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.
Tada S, Okuno T, Shimizu M, Sakai Y, Sumi-Akamaru H, Kinoshita M, Yamashita K, Sanda E, Choong CJ, Namba A, Sasaki T, Koda T, Takata K, Miyagawa S, Sawa Y, Nakatsuji Y, Mochizuki H. Tada S, et al. Among authors: shimizu m. Sci Rep. 2019 Mar 27;9(1):5252. doi: 10.1038/s41598-019-41771-4. Sci Rep. 2019. PMID: 30918303 Free PMC article.
Astrocyte metabolism in multiple sclerosis investigated by 1-C-11 acetate PET.
Kato H, Okuno T, Isohashi K, Koda T, Shimizu M, Mochizuki H, Nakatsuji Y, Hatazawa J. Kato H, et al. Among authors: shimizu m. J Cereb Blood Flow Metab. 2021 Feb;41(2):369-379. doi: 10.1177/0271678X20911469. Epub 2020 Mar 13. J Cereb Blood Flow Metab. 2021. PMID: 32169013 Free PMC article.
Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase.
Koda T, Namba A, Kinoshita M, Nakatsuji Y, Sugimoto T, Sakakibara K, Tada S, Shimizu M, Yamashita K, Takata K, Ishikura T, Murata S, Beppu S, Kumanogoh A, Mochizuki H, Okuno T. Koda T, et al. Among authors: shimizu m. J Neuroinflammation. 2020 Mar 13;17(1):82. doi: 10.1186/s12974-020-01757-w. J Neuroinflammation. 2020. PMID: 32169103 Free PMC article.
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation.
Shimizu M, Okuno T, Kinoshita M, Sumi H, Fujimura H, Yamashita K, Sugimoto T, Sakakibara S, Sakakibara K, Koda T, Tada S, Ishikura T, Murata H, Beppu S, Shiraishi N, Sugiyama Y, Nakatsuji Y, Kumanogoh A, Mochizuki H. Shimizu M, et al. Sci Rep. 2020 Aug 6;10(1):13274. doi: 10.1038/s41598-020-70203-x. Sci Rep. 2020. PMID: 32764561 Free PMC article.
6,039 results