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Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells.
Hong SW, Shin JS, Moon JH, Jung SA, Koh DI, Ryu Y, Park YS, Kim DY, Park SS, Hong JK, Kim EH, Kim MJ, Jeong HR, Bae IH, Ahn YG, Suh KH, Cho IJ, Kang JS, Hong YS, Lee JS, Jin DH, Kim TW. Hong SW, et al. Among authors: lee js. Invest New Drugs. 2020 Dec;38(6):1696-1706. doi: 10.1007/s10637-020-00956-9. Epub 2020 May 27. Invest New Drugs. 2020. PMID: 32462369
YM155 induces EGFR suppression in pancreatic cancer cells.
Na YS, Yang SJ, Kim SM, Jung KA, Moon JH, Shin JS, Yoon DH, Hong YS, Ryu MH, Lee JL, Lee JS, Kim TW. Na YS, et al. Among authors: lee js, lee jl. PLoS One. 2012;7(6):e38625. doi: 10.1371/journal.pone.0038625. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723871 Free PMC article.
NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants.
Shin JS, Hong SW, Moon JH, Kim JS, Jung KA, Kim SM, Lee DH, Kim I, Yoon SJ, Lee CG, Choi EK, Lee JY, Kim KP, Hong YS, Lee JL, Kim B, Choi EK, Lee JS, Jin DH, Kim TW. Shin JS, et al. Among authors: lee dh, lee cg, lee js, lee jy, lee jl. Invest New Drugs. 2014 Jun;32(3):389-99. doi: 10.1007/s10637-013-0039-4. Epub 2013 Oct 31. Invest New Drugs. 2014. PMID: 24173966
Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells.
Jung SA, Park YM, Hong SW, Moon JH, Shin JS, Lee HR, Ha SH, Lee DH, Kim JH, Kim SM, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Jin DH, Kim T. Jung SA, et al. Among authors: lee dh, lee js, lee hr. J Biol Chem. 2015 Apr 17;290(16):9974-85. doi: 10.1074/jbc.M114.600874. Epub 2015 Jan 29. J Biol Chem. 2015. PMID: 25635055 Free PMC article.
A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer.
Moon JH, Shin JS, Hong SW, Jung SA, Hwang IY, Kim JH, Choi EK, Ha SH, Kim JS, Kim KM, Hong DW, Kim D, Kim YS, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Hattersley M, Jin DH, Kim TW. Moon JH, et al. Among authors: lee js. Oncotarget. 2015 Sep 29;6(29):26895-908. doi: 10.18632/oncotarget.4822. Oncotarget. 2015. PMID: 26314849 Free PMC article.
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