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Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids.
Nat Chem. 2020 Jun;12(6):535-544. doi: 10.1038/s41557-020-0472-x. Epub 2020 May 29.
Nat Chem. 2020.
PMID: 32472101
Free PMC article.
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design.
Dunkelmann DL, Oehm SB, Beattie AT, Chin JW.
Dunkelmann DL, et al. Among authors: beattie at.
Nat Chem. 2021 Nov;13(11):1110-1117. doi: 10.1038/s41557-021-00764-5. Epub 2021 Aug 23.
Nat Chem. 2021.
PMID: 34426682
Free PMC article.
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Mechanism-based traps enable protease and hydrolase substrate discovery.
Tang S, Beattie AT, Kafkova L, Petris G, Huguenin-Dezot N, Fiedler M, Freeman M, Chin JW.
Tang S, et al. Among authors: beattie at.
Nature. 2022 Feb;602(7898):701-707. doi: 10.1038/s41586-022-04414-9. Epub 2022 Feb 16.
Nature. 2022.
PMID: 35173328
Free PMC article.
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Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.
Beattie AT, Dunkelmann DL, Chin JW.
Beattie AT, et al.
Nat Chem. 2023 Jul;15(7):948-959. doi: 10.1038/s41557-023-01232-y. Epub 2023 Jun 15.
Nat Chem. 2023.
PMID: 37322102
Free PMC article.
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