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Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.
Bayerle A, Marsching C, Rabionet M, Dworski S, Kamani MA, Chitraju C, Gluchowski NL, Gabriel KR, Herzer S, Jennemann R, Levade T, Medin JA, Sandhoff R. Bayerle A, et al. Among authors: medin ja. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Sep;1865(9):158741. doi: 10.1016/j.bbalip.2020.158741. Epub 2020 May 28. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32474112
Stress-induced apoptosis is not mediated by endolysosomal ceramide.
Ségui B, Bezombes C, Uro-Coste E, Medin JA, Andrieu-Abadie N, Augé N, Brouchet A, Laurent G, Salvayre R, Jaffrézou JP, Levade T. Ségui B, et al. Among authors: medin ja. FASEB J. 2000 Jan;14(1):36-47. doi: 10.1096/fasebj.14.1.36. FASEB J. 2000. PMID: 10627278
Systemic ceramide accumulation leads to severe and varied pathological consequences.
Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA. Alayoubi AM, et al. Among authors: medin ja. EMBO Mol Med. 2013 Jun;5(6):827-42. doi: 10.1002/emmm.201202301. Epub 2013 May 16. EMBO Mol Med. 2013. PMID: 23681708 Free PMC article.
Markedly perturbed hematopoiesis in acid ceramidase deficient mice.
Dworski S, Berger A, Furlonger C, Moreau JM, Yoshimitsu M, Trentadue J, Au BC, Paige CJ, Medin JA. Dworski S, et al. Among authors: medin ja. Haematologica. 2015 May;100(5):e162-5. doi: 10.3324/haematol.2014.108530. Epub 2015 Feb 14. Haematologica. 2015. PMID: 25682603 Free PMC article. No abstract available.
174 results