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A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ42 and tau-induced pathophysiological effects on long-term potentiation.
Caneus J, Akanda N, Rumsey JW, Guo X, Jackson M, Long CJ, Sommerhage F, Georgieva S, Kanaan NM, Morgan D, Hickman JJ. Caneus J, et al. Alzheimers Dement (N Y). 2020 May 27;6(1):e12029. doi: 10.1002/trc2.12029. eCollection 2020. Alzheimers Dement (N Y). 2020. PMID: 32490141 Free PMC article.
Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays.
Caneus J, Autar K, Akanda N, Grillo M, Long C, Jackson M, Lindquist S, Guo X, Morgan D, Hickman JJ. Caneus J, et al. Res Sq [Preprint]. 2024 May 20:rs.3.rs-4313679. doi: 10.21203/rs.3.rs-4313679/v1. Res Sq. 2024. Update in: Sci Rep. 2024 Oct 22;14(1):24875. doi: 10.1038/s41598-024-73869-9 PMID: 38826367 Free PMC article. Updated. Preprint.