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Advances in therapeutic peptides targeting G protein-coupled receptors.
Davenport AP, Scully CCG, de Graaf C, Brown AJH, Maguire JJ. Davenport AP, et al. Among authors: brown ajh. Nat Rev Drug Discov. 2020 Jun;19(6):389-413. doi: 10.1038/s41573-020-0062-z. Epub 2020 Mar 19. Nat Rev Drug Discov. 2020. PMID: 32494050 Review.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M. O'Brien A, et al. Among authors: brown ga, brown sh, brown ajh. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31447084
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Nyimanu D, Kay RG, Kuc RE, Brown AJH, Gribble FM, Maguire JJ, Davenport AP. Nyimanu D, et al. Among authors: brown ajh. Peptides. 2021 Nov;145:170642. doi: 10.1016/j.peptides.2021.170642. Epub 2021 Aug 26. Peptides. 2021. PMID: 34455010 Free PMC article.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free PMC article. Clinical Trial.
Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor.
Williams TL, Verdon G, Kuc RE, Currinn H, Bender B, Solcan N, Schlenker O, Macrae RGC, Brown J, Schütz M, Zhukov A, Sinha S, de Graaf C, Gräf S, Maguire JJ, Brown AJH, Davenport AP. Williams TL, et al. Among authors: brown ajh. Nat Commun. 2024 Dec 27;15(1):10714. doi: 10.1038/s41467-024-55381-w. Nat Commun. 2024. PMID: 39730334 Free PMC article.
35 results