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Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.
Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ. Shen Y, et al. Among authors: hiroyasu s. Exp Mol Med. 2018 May 30;50(5):1-11. doi: 10.1038/s12276-018-0095-0. Exp Mol Med. 2018. PMID: 29849046 Free PMC article.
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ. Russo V, et al. Among authors: hiroyasu s. Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0. Sci Rep. 2018. PMID: 29946113 Free PMC article.
Proteases in Pemphigoid Diseases.
Hiroyasu S, Turner CT, Richardson KC, Granville DJ. Hiroyasu S, et al. Front Immunol. 2019 Jun 26;10:1454. doi: 10.3389/fimmu.2019.01454. eCollection 2019. Front Immunol. 2019. PMID: 31297118 Free PMC article. Review.
Granzyme B as a therapeutic target for wound healing.
Turner CT, Hiroyasu S, Granville DJ. Turner CT, et al. Among authors: hiroyasu s. Expert Opin Ther Targets. 2019 Sep;23(9):745-754. doi: 10.1080/14728222.2019.1661380. Epub 2019 Sep 4. Expert Opin Ther Targets. 2019. PMID: 31461387 Review.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Hiroyasu S, Zeglinski MR, Zhao H, Pawluk MA, Turner CT, Kasprick A, Tateishi C, Nishie W, Burleigh A, Lennox PA, Van Laeken N, Carr NJ, Petersen F, Crawford RI, Shimizu H, Tsuruta D, Ludwig RJ, Granville DJ. Hiroyasu S, et al. Nat Commun. 2021 Jan 12;12(1):302. doi: 10.1038/s41467-020-20604-3. Nat Commun. 2021. PMID: 33436591 Free PMC article.
Granzyme B mediates impaired healing of pressure injuries in aged skin.
Turner CT, Bolsoni J, Zeglinski MR, Zhao H, Ponomarev T, Richardson K, Hiroyasu S, Schmid E, Papp A, Granville DJ. Turner CT, et al. Among authors: hiroyasu s. NPJ Aging Mech Dis. 2021 Mar 5;7(1):6. doi: 10.1038/s41514-021-00059-6. NPJ Aging Mech Dis. 2021. PMID: 33674592 Free PMC article.
Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1.
Obasanmi G, Zeglinski MR, Hardie E, Wilhelm AC, Turner CT, Hiroyasu S, Boivin WA, Tian Y, Zhao H, To E, Cui JZ, Xi J, Yoo HS, Uppal M, Granville DJ, Matsubara JA. Obasanmi G, et al. Among authors: hiroyasu s. Lab Invest. 2023 Jun;103(6):100123. doi: 10.1016/j.labinv.2023.100123. Epub 2023 Feb 26. Lab Invest. 2023. PMID: 36849037 Free article.
Granzyme serine proteases in inflammation and rheumatic diseases.
Aubert A, Jung K, Hiroyasu S, Pardo J, Granville DJ. Aubert A, et al. Among authors: hiroyasu s. Nat Rev Rheumatol. 2024 Jun;20(6):361-376. doi: 10.1038/s41584-024-01109-5. Epub 2024 Apr 30. Nat Rev Rheumatol. 2024. PMID: 38689140 Review.
68 results