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Page 1
Enterotoxins can support CAR T cells against solid tumors.
von Scheidt B, Wang M, Oliver AJ, Chan JD, Jana MK, Ali AI, Clow F, Fraser JD, Quinn KM, Darcy PK, Kershaw MH, Slaney CY. von Scheidt B, et al. Among authors: chan jd. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25229-25235. doi: 10.1073/pnas.1904618116. Epub 2019 Nov 25. Proc Natl Acad Sci U S A. 2019. PMID: 31767744 Free PMC article.
Tissue-specific tumor microenvironments influence responses to immunotherapies.
Oliver AJ, Davey AS, Keam SP, Mardiana S, Chan JD, von Scheidt B, Beavis PA, House IG, Van Audernaerde JR, Darcy PK, Kershaw MH, Slaney CY. Oliver AJ, et al. Among authors: chan jd. Clin Transl Immunology. 2019 Nov 21;8(11):e1094. doi: 10.1002/cti2.1094. eCollection 2019. Clin Transl Immunology. 2019. PMID: 31768254 Free PMC article.
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity.
Lai J, Mardiana S, House IG, Sek K, Henderson MA, Giuffrida L, Chen AXY, Todd KL, Petley EV, Chan JD, Carrington EM, Lew AM, Solomon BJ, Trapani JA, Kedzierska K, Evrard M, Vervoort SJ, Waithman J, Darcy PK, Beavis PA. Lai J, et al. Among authors: chan jd. Nat Immunol. 2020 Aug;21(8):914-926. doi: 10.1038/s41590-020-0676-7. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424363
MAIT cells regulate NK cell-mediated tumor immunity.
Petley EV, Koay HF, Henderson MA, Sek K, Todd KL, Keam SP, Lai J, House IG, Li J, Zethoven M, Chen AXY, Oliver AJ, Michie J, Freeman AJ, Giuffrida L, Chan JD, Pizzolla A, Mak JYW, McCulloch TR, Souza-Fonseca-Guimaraes F, Kearney CJ, Millen R, Ramsay RG, Huntington ND, McCluskey J, Oliaro J, Fairlie DP, Neeson PJ, Godfrey DI, Beavis PA, Darcy PK. Petley EV, et al. Among authors: chan jd. Nat Commun. 2021 Aug 6;12(1):4746. doi: 10.1038/s41467-021-25009-4. Nat Commun. 2021. PMID: 34362900 Free PMC article.
A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer.
Ali AI, Wang M, von Scheidt B, Dominguez PM, Harrison AJ, Tantalo DGM, Kang J, Oliver AJ, Chan JD, Du X, Bai Y, Lee B, Johnstone RW, Darcy PK, Kershaw MH, Slaney CY. Ali AI, et al. Among authors: chan jd. Clin Cancer Res. 2021 Nov 15;27(22):6222-6234. doi: 10.1158/1078-0432.CCR-21-1141. Epub 2021 Sep 2. Clin Cancer Res. 2021. PMID: 34475103
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity.
House IG, Derrick EB, Sek K, Chen AXY, Li J, Lai J, Todd KL, Munoz I, Michie J, Chan CW, Huang YK, Chan JD, Petley EV, Tong J, Nguyen D, Engel S, Savas P, Hogg SJ, Vervoort SJ, Kearney CJ, Burr ML, Lam EYN, Gilan O, Bedoui S, Johnstone RW, Dawson MA, Loi S, Darcy PK, Beavis PA. House IG, et al. Among authors: chan jd, chan cw. Cell Rep. 2023 Aug 29;42(8):113014. doi: 10.1016/j.celrep.2023.113014. Epub 2023 Aug 21. Cell Rep. 2023. PMID: 37605534 Free article.
105 results