Elseginy SA - Search Results

1

Selective inhibition of Rhizopus eumelanin biosynthesis by novel natural product scaffold-based designs caused significant inhibition of fungal pathogenesis.

Soliman SSM, Hamdy R, Elseginy SA, Gebremariam T, Hamoda AM, Madkour M, Venkatachalam T, Ershaid MN, Mohammad MG, Chamilos G, Ibrahim AS. Soliman SSM, et al. Among authors: elseginy sa. Biochem J. 2020 Jul 17;477(13):2489-2507. doi: 10.1042/BCJ20200310. Biochem J. 2020. PMID: 32538426 Free PMC article.

2

New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2.

Hamdy R, Elseginy SA, Ziedan NI, Jones AT, Westwell AD. Hamdy R, et al. Among authors: elseginy sa. Molecules. 2019 Apr 2;24(7):1274. doi: 10.3390/molecules24071274. Molecules. 2019. PMID: 30986908 Free PMC article.

3

Design and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene.

Hamdy R, Soliman SSM, Alsaadi AI, Fayed B, Hamoda AM, Elseginy SA, Husseiny MI, Ibrahim AS. Hamdy R, et al. Among authors: elseginy sa. Eur J Pharm Sci. 2020 May 30;148:105327. doi: 10.1016/j.ejps.2020.105327. Epub 2020 Apr 6. Eur J Pharm Sci. 2020. PMID: 32272212 Free PMC article.

4

Design, synthesis, and computational validation of novel compounds selectively targeting HER2-expressing breast cancer.

Elseginy SA, Hamdy R, Menon V, Almehdi AM, El-Awady R, Soliman SSM. Elseginy SA, et al. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127658. doi: 10.1016/j.bmcl.2020.127658. Epub 2020 Oct 29. Bioorg Med Chem Lett. 2020. PMID: 33130288

5

Critical discovery and synthesis of novel antibacterial and resistance-modifying agents inspired by plant phytochemical defense mechanisms.

Soliman SSM, Saeed BQ, Elseginy SA, Al-Marzooq F, Ahmady IM, El-Keblawy AA, Hamdy R. Soliman SSM, et al. Among authors: elseginy sa. Chem Biol Interact. 2021 Jan 5;333:109318. doi: 10.1016/j.cbi.2020.109318. Epub 2020 Nov 10. Chem Biol Interact. 2021. PMID: 33186599

6

Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2.

Hamdy R, Elseginy SA, Ziedan NI, El-Sadek M, Lashin E, Jones AT, Westwell AD. Hamdy R, et al. Among authors: elseginy sa. Int J Mol Sci. 2020 Nov 26;21(23):8980. doi: 10.3390/ijms21238980. Int J Mol Sci. 2020. PMID: 33256166 Free PMC article.

7

Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases.

Elseginy SA, Fayed B, Hamdy R, Mahrous N, Mostafa A, Almehdi AM, S M Soliman S. Elseginy SA, et al. Bioorg Med Chem Lett. 2021 Jul 1;43:128099. doi: 10.1016/j.bmcl.2021.128099. Epub 2021 May 10. Bioorg Med Chem Lett. 2021. PMID: 33984473 Free PMC article.

8

Design, Synthesis and Biological Evaluation of Spiro Cyclohexane-1,2- Quinazoline Derivatives as Potent Dipeptidyl Peptidase IV Inhibitors.

Syam YM, El-Karim SSA, Nasr T, Elseginy SA, Anwar MM, Kamel MM, Ali HF. Syam YM, et al. Among authors: elseginy sa. Mini Rev Med Chem. 2019;19(3):250-269. doi: 10.2174/1389557517666170828121018. Mini Rev Med Chem. 2019. PMID: 28847268

9

Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells.

Batran RZ, Kassem AF, Abbas EMH, Elseginy SA, Mounier MM. Batran RZ, et al. Among authors: elseginy sa. Bioorg Med Chem. 2018 Jul 23;26(12):3474-3490. doi: 10.1016/j.bmc.2018.05.022. Epub 2018 May 16. Bioorg Med Chem. 2018. PMID: 29793751

10

Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis.

Mohamed TK, Batran RZ, Elseginy SA, Ali MM, Mahmoud AE. Mohamed TK, et al. Among authors: elseginy sa. Bioorg Chem. 2019 Apr;85:253-273. doi: 10.1016/j.bioorg.2018.12.040. Epub 2019 Jan 3. Bioorg Chem. 2019. PMID: 30641320

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