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Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, Wang Z, Laws GM, Griffiths TG, Kuhls MC, Chen Q, Knemeyer I, Marsh DJ, Mitra K, Lebron J, Sistare FD. Kang W, et al. Among authors: lebron j. Toxicol Sci. 2020 Sep 1;177(1):121-139. doi: 10.1093/toxsci/kfaa094. Toxicol Sci. 2020. PMID: 32559289
Adaptation of the WHO guideline for residual DNA in parenteral vaccines produced on continuous cell lines to a limit for oral vaccines.
Lebron JA, Troilol PJ, Pacchione S, Griffiths TG, Harper LB, Mixson LA, Jackson BE, Michna L, Barnum AB, Denisova L, Johnson CN, Maurer KL, Morgan-Hoffman S, Niu Z, Roden DF, Wang Z, Wolf JJ, Hamilton TR, Laux KM, Soper KA, Ledwith BJ. Lebron JA, et al. Dev Biol (Basel). 2006;123:35-44; discussion 55-73. Dev Biol (Basel). 2006. PMID: 16566435
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.
Li Y, Evers R, Hafey MJ, Cheon K, Duong H, Lynch D, LaFranco-Scheuch L, Pacchione S, Tamburino AM, Tanis KQ, Geddes K, Holder D, Zhang NR, Kang W, Gonzalez RJ, Galijatovic-Idrizbegovic A, Pearson KM, Lebron JA, Glaab WE, Sistare FD. Li Y, et al. Among authors: lebron ja. Toxicol Sci. 2019 Jul 1;170(1):180-198. doi: 10.1093/toxsci/kfz079. Toxicol Sci. 2019. PMID: 30903168
Can Galactose Be Converted to Glucose in HepG2 Cells? Improving the in Vitro Mitochondrial Toxicity Assay for the Assessment of Drug Induced Liver Injury.
Xu Q, Liu L, Vu H, Kuhls M, Aslamkhan AG, Liaw A, Yu Y, Kaczor A, Ruth M, Wei C, Imredy J, Lebron J, Pearson K, Gonzalez R, Mitra K, Sistare FD. Xu Q, et al. Among authors: lebron j. Chem Res Toxicol. 2019 Aug 19;32(8):1528-1544. doi: 10.1021/acs.chemrestox.9b00033. Epub 2019 Jul 18. Chem Res Toxicol. 2019. PMID: 31271030
A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.
Aslamkhan AG, Michna L, Podtelezhnikov A, Vlasakova K, Suemizu H, Ohnishi Y, Liu L, Lane P, Xu Q, Kuhls MC, Wang Z, Pacchione S, Erdos Z, Tracy RW, Koeplinger K, Muniappa N, Valentine J, Galijatovic-Idrizbegovic A, Glaab WE, Sistare FD, Lebron J. Aslamkhan AG, et al. Among authors: lebron j. Toxicol Res (Camb). 2024 Jan 11;13(1):tfad120. doi: 10.1093/toxres/tfad120. eCollection 2024 Feb. Toxicol Res (Camb). 2024. PMID: 38223529
56 results