Sistare FD - Search Results

1

Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.

Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, Wang Z, Laws GM, Griffiths TG, Kuhls MC, Chen Q, Knemeyer I, Marsh DJ, Mitra K, Lebron J, Sistare FD. Kang W, et al. Among authors: sistare fd. Toxicol Sci. 2020 Sep 1;177(1):121-139. doi: 10.1093/toxsci/kfaa094. Toxicol Sci. 2020. PMID: 32559289

2

Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.

Powley MW, Frederick CB, Sistare FD, DeGeorge JJ. Powley MW, et al. Among authors: sistare fd. Chem Res Toxicol. 2009 Feb;22(2):257-62. doi: 10.1021/tx8004373. Chem Res Toxicol. 2009. PMID: 19170595

3

Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury.

Yu Y, Jin H, Holder D, Ozer JS, Villarreal S, Shughrue P, Shi S, Figueroa DJ, Clouse H, Su M, Muniappa N, Troth SP, Bailey W, Seng J, Aslamkhan AG, Thudium D, Sistare FD, Gerhold DL. Yu Y, et al. Among authors: sistare fd. Nat Biotechnol. 2010 May;28(5):470-7. doi: 10.1038/nbt.1624. Nat Biotechnol. 2010. PMID: 20458317

4

A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase.

Bailey WJ, Holder D, Patel H, Devlin P, Gonzalez RJ, Hamilton V, Muniappa N, Hamlin DM, Thomas CE, Sistare FD, Glaab WE. Bailey WJ, et al. Among authors: sistare fd. Toxicol Sci. 2012 Dec;130(2):229-44. doi: 10.1093/toxsci/kfs243. Epub 2012 Aug 7. Toxicol Sci. 2012. PMID: 22872058

5

Evaluation of the relative performance of 12 urinary biomarkers for renal safety across 22 rat sensitivity and specificity studies.

Vlasakova K, Erdos Z, Troth SP, McNulty K, Chapeau-Campredon V, Mokrzycki N, Muniappa N, Gu YZ, Holder D, Bailey WJ, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: sistare fd. Toxicol Sci. 2014 Mar;138(1):3-20. doi: 10.1093/toxsci/kft330. Epub 2013 Dec 21. Toxicol Sci. 2014. PMID: 24361871

6

Toxicogenomics in drug development: a match made in heaven?

Qin C, Tanis KQ, Podtelezhnikov AA, Glaab WE, Sistare FD, DeGeorge JJ. Qin C, et al. Among authors: sistare fd. Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):847-9. doi: 10.1080/17425255.2016.1175437. Epub 2016 Apr 21. Expert Opin Drug Metab Toxicol. 2016. PMID: 27050123 No abstract available.

7

The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development.

Sistare FD, Mattes WB, LeCluyse EL. Sistare FD, et al. ILAR J. 2016 Dec;57(2):186-211. doi: 10.1093/ilar/ilw025. ILAR J. 2016. PMID: 28053072

8

Antibiotic-Induced Elevations of Plasma Bile Acids in Rats Independent of Bsep Inhibition.

Li Y, Hafey MJ, Duong H, Evers R, Cheon K, Holder DJ, Galijatovic-Idrizbegovic A, Sistare FD, Glaab WE. Li Y, et al. Among authors: sistare fd. Toxicol Sci. 2017 May 1;157(1):30-40. doi: 10.1093/toxsci/kfx015. Toxicol Sci. 2017. PMID: 28108666

9

Response of Novel Skeletal Muscle Biomarkers in Dogs to Drug-Induced Skeletal Muscle Injury or Sustained Endurance Exercise.

Vlasakova K, Lane P, Michna L, Muniappa N, Sistare FD, Glaab WE. Vlasakova K, et al. Among authors: sistare fd. Toxicol Sci. 2017 Apr 1;156(2):422-427. doi: 10.1093/toxsci/kfw262. Toxicol Sci. 2017. PMID: 28115646

10

A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury.

Bailey WJ, Barnum JE, Erdos Z, LaFranco-Scheuch L, Lane P, Vlasakova K, Sistare FD, Glaab WE. Bailey WJ, et al. Among authors: sistare fd. Toxicol Sci. 2019 Mar 1;168(1):110-125. doi: 10.1093/toxsci/kfy282. Toxicol Sci. 2019. PMID: 30496518

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