Langen R - Search Results

1

Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells.

Lo CH, Pandey NK, Lim CK, Ding Z, Tao M, Thomas DD, Langen R, Sachs JN. Lo CH, et al. Among authors: langen r. ACS Chem Neurosci. 2020 Aug 5;11(15):2286-2295. doi: 10.1021/acschemneuro.0c00226. Epub 2020 Jul 7. ACS Chem Neurosci. 2020. PMID: 32568514

2

A compact beta model of huntingtin toxicity.

Zhang QC, Yeh TL, Leyva A, Frank LG, Miller J, Kim YE, Langen R, Finkbeiner S, Amzel ML, Ross CA, Poirier MA. Zhang QC, et al. Among authors: langen r. J Biol Chem. 2011 Mar 11;286(10):8188-8196. doi: 10.1074/jbc.M110.192013. Epub 2011 Jan 5. J Biol Chem. 2011. PMID: 21209075 Free PMC article.

3

Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, Langen R, Weiss A, Caricasole A. Fodale V, et al. Among authors: langen r. PLoS One. 2014 Dec 2;9(12):e112262. doi: 10.1371/journal.pone.0112262. eCollection 2014. PLoS One. 2014. PMID: 25464275 Free PMC article.

4

Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.

Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya JG, King JA, Langen R, Schmid MF, Chiu W. Darrow MC, et al. Among authors: langen r. J Biol Chem. 2015 Jul 10;290(28):17451-61. doi: 10.1074/jbc.M115.655373. Epub 2015 May 20. J Biol Chem. 2015. PMID: 25995452 Free PMC article.

5

Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils.

Isas JM, Langen R, Siemer AB. Isas JM, et al. Among authors: langen r. Biochemistry. 2015 Jun 30;54(25):3942-9. doi: 10.1021/acs.biochem.5b00281. Epub 2015 Jun 16. Biochemistry. 2015. PMID: 26020223 Free PMC article.

6

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms.

Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R. Pandey NK, et al. Among authors: langen r, langen j. J Biol Chem. 2018 Feb 16;293(7):2597-2605. doi: 10.1074/jbc.M117.813667. Epub 2017 Dec 27. J Biol Chem. 2018. PMID: 29282287 Free PMC article.

7

Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin.

Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A. Ko J, et al. Among authors: langen r. Hum Mol Genet. 2018 Jul 1;27(13):2330-2343. doi: 10.1093/hmg/ddy141. Hum Mol Genet. 2018. PMID: 29912367 Free PMC article.

8

The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract.

Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R. Bravo-Arredondo JM, et al. Among authors: langen r. J Biol Chem. 2018 Dec 21;293(51):19613-19623. doi: 10.1074/jbc.RA118.004808. Epub 2018 Oct 12. J Biol Chem. 2018. PMID: 30315108 Free PMC article.

9

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL.

Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS. Vasquez-Montes V, et al. Among authors: langen r. Biochim Biophys Acta Proteins Proteom. 2019 Jul-Aug;1867(7-8):691-700. doi: 10.1016/j.bbapap.2019.04.006. Epub 2019 Apr 18. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 31004798 Free PMC article.

10

Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms.

Tao M, Pandey NK, Barnes R, Han S, Langen R. Tao M, et al. Among authors: langen r. Structure. 2019 Oct 1;27(10):1570-1580.e4. doi: 10.1016/j.str.2019.08.003. Epub 2019 Aug 26. Structure. 2019. PMID: 31466833 Free PMC article.

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