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A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL.
Tong B, Spradlin JN, Novaes LFT, Zhang E, Hu X, Moeller M, Brittain SM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ, Nomura DK. Tong B, et al. Among authors: maimone tj. ACS Chem Biol. 2020 Jul 17;15(7):1788-1794. doi: 10.1021/acschembio.0c00348. Epub 2020 Jun 25. ACS Chem Biol. 2020. PMID: 32568522 Free PMC article.
Synthesis and Study of the Antimalarial Cardamom Peroxide.
Hu X, Lim P, Fairhurst RM, Maimone TJ. Hu X, et al. Among authors: maimone tj. Tetrahedron. 2018 Jun 28;74(26):3358-3369. doi: 10.1016/j.tet.2018.03.045. Epub 2018 Mar 26. Tetrahedron. 2018. PMID: 30319159 Free PMC article.
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.
Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ, Nomura DK. Berdan CA, et al. Among authors: maimone tj. Cell Chem Biol. 2019 Jul 18;26(7):1027-1035.e22. doi: 10.1016/j.chembiol.2019.03.016. Epub 2019 May 9. Cell Chem Biol. 2019. PMID: 31080076 Free PMC article.
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.
Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK. Spradlin JN, et al. Among authors: maimone tj. Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209351 Free PMC article.
62 results