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A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL.
Tong B, Spradlin JN, Novaes LFT, Zhang E, Hu X, Moeller M, Brittain SM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ, Nomura DK. Tong B, et al. Among authors: nomura dk. ACS Chem Biol. 2020 Jul 17;15(7):1788-1794. doi: 10.1021/acschembio.0c00348. Epub 2020 Jun 25. ACS Chem Biol. 2020. PMID: 32568522 Free PMC article.
Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.
Hunerdosse DM, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh JR, Zhong S, Nomura DK. Hunerdosse DM, et al. Among authors: nomura dk. ACS Chem Biol. 2014 Dec 19;9(12):2905-13. doi: 10.1021/cb500717g. Epub 2014 Nov 5. ACS Chem Biol. 2014. PMID: 25343321 Free PMC article.
Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, Nomura DK, Kwon O, Hsu KL, Cravatt BF. Chang JW, et al. Among authors: nomura dk. ACS Chem Biol. 2015 Apr 17;10(4):925-32. doi: 10.1021/cb500893q. Epub 2015 Jan 20. ACS Chem Biol. 2015. PMID: 25602368 Free PMC article.
183 results