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Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis-platin.
Haghdoost M, Golbaghi G, Létourneau M, Patten SA, Castonguay A. Haghdoost M, et al. Among authors: castonguay a. Eur J Med Chem. 2017 May 26;132:282-293. doi: 10.1016/j.ejmech.2017.03.029. Epub 2017 Mar 18. Eur J Med Chem. 2017. PMID: 28371640
Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos.
Golbaghi G, Haghdoost MM, Yancu D, Santos YLL, Doucet N, Patten SA, Sanderson JT, Castonguay A. Golbaghi G, et al. Among authors: castonguay a. Organometallics. 2019 Feb 11;38(3):702-711. doi: 10.1021/acs.organomet.8b00897. Epub 2019 Jan 31. Organometallics. 2019. PMID: 31762529 Free PMC article.
279 results