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EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Fernandez-Salas E, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey J, Zhou Y, Chen J, Tang G, Wang S. Rej RK, et al. J Med Chem. 2020 Jul 9;63(13):7252-7267. doi: 10.1021/acs.jmedchem.0c00479. Epub 2020 Jun 24. J Med Chem. 2020. PMID: 32580550 Free PMC article.
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
Rej RK, Wang C, Lu J, Wang M, Petrunak E, Zawacki KP, McEachern D, Yang CY, Wang L, Li R, Chinnaswamy K, Wen B, Sun D, Stuckey JA, Zhou Y, Chen J, Tang G, Wang S. Rej RK, et al. J Med Chem. 2021 Oct 14;64(19):14540-14556. doi: 10.1021/acs.jmedchem.1c01059. Epub 2021 Oct 6. J Med Chem. 2021. PMID: 34613724 Free PMC article.
Discovery of Pyrrolo[2,3-c]pyridines as Potent and Reversible LSD1 Inhibitors.
Zheng C, Rej RK, Wang M, Huang L, Fernandez-Salas E, Yang CY, Wang S. Zheng C, et al. Among authors: rej rk. ACS Med Chem Lett. 2023 Sep 21;14(10):1389-1395. doi: 10.1021/acsmedchemlett.3c00292. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849536 Free PMC article.
Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer.
Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. Acharyya RK, et al. Among authors: rej rk. J Med Chem. 2024 Nov 14;67(21):19010-19037. doi: 10.1021/acs.jmedchem.4c01521. Epub 2024 Nov 1. J Med Chem. 2024. PMID: 39485242
Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).
Rej RK, Hu B, Chen Z, Acharyya RK, Wu D, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Nishimura LS, Gersch CL, Wang M, Wen B, Sun D, Carlson K, Katzenellenbogen JA, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Rae JM, Wang S. Rej RK, et al. J Med Chem. 2024 Dec 12;67(23):20933-20965. doi: 10.1021/acs.jmedchem.4c01401. Epub 2024 Nov 25. J Med Chem. 2024. PMID: 39585895
15 results