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Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia.
Dron JS, Dilliott AA, Lawson A, McIntyre AD, Davis BD, Wang J, Cao H, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Dron JS, et al. Among authors: cao h. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1935-1941. doi: 10.1161/ATVBAHA.120.314168. Epub 2020 Jun 25. Arterioscler Thromb Vasc Biol. 2020. PMID: 32580631 Free article.
An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.
Johansen CT, Wang J, Lanktree MB, McIntyre AD, Ban MR, Martins RA, Kennedy BA, Hassell RG, Visser ME, Schwartz SM, Voight BF, Elosua R, Salomaa V, O'Donnell CJ, Dallinga-Thie GM, Anand SS, Yusuf S, Huff MW, Kathiresan S, Cao H, Hegele RA. Johansen CT, et al. Among authors: cao h. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1916-26. doi: 10.1161/ATVBAHA.111.226365. Epub 2011 May 19. Arterioscler Thromb Vasc Biol. 2011. PMID: 21597005 Free PMC article.
Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia.
Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Péterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA. Johansen CT, et al. Among authors: cao h. Circ Cardiovasc Genet. 2012 Feb 1;5(1):66-72. doi: 10.1161/CIRCGENETICS.111.960864. Epub 2011 Dec 1. Circ Cardiovasc Genet. 2012. PMID: 22135386 Free PMC article.
Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically.
Wang J, Dron JS, Ban MR, Robinson JF, McIntyre AD, Alazzam M, Zhao PJ, Dilliott AA, Cao H, Huff MW, Rhainds D, Low-Kam C, Dubé MP, Lettre G, Tardif JC, Hegele RA. Wang J, et al. Among authors: cao h. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2439-2445. doi: 10.1161/ATVBAHA.116.308027. Epub 2016 Oct 20. Arterioscler Thromb Vasc Biol. 2016. PMID: 27765764
Severe hypertriglyceridemia is primarily polygenic.
Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Dron JS, et al. Among authors: cao h. J Clin Lipidol. 2019 Jan-Feb;13(1):80-88. doi: 10.1016/j.jacl.2018.10.006. Epub 2018 Oct 24. J Clin Lipidol. 2019. PMID: 30466821 Free article.
The polygenic nature of mild-to-moderate hypertriglyceridemia.
Dron JS, Wang J, McIntyre AD, Cao H, Hegele RA. Dron JS, et al. Among authors: cao h. J Clin Lipidol. 2020 Jan-Feb;14(1):28-34.e2. doi: 10.1016/j.jacl.2020.01.003. Epub 2020 Jan 14. J Clin Lipidol. 2020. PMID: 32033914
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