Locher K - Search Results

1

Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture.

Turk JR, Deaton AM, Yin J, Stolina M, Felx M, Boyd G, Bienvenu JG, Varela A, Guillot M, Holdsworth G, Wolfreys A, Dwyer D, Kumar SV, de Koning EM, Qu Y, Engwall M, Locher K, Ward LD, Glaus C, He YD, Boyce RW. Turk JR, et al. Among authors: locher k. Regul Toxicol Pharmacol. 2020 Aug;115:104697. doi: 10.1016/j.yrtph.2020.104697. Epub 2020 Jun 23. Regul Toxicol Pharmacol. 2020. PMID: 32590049 Free article.

2

Carcinogenicity risk assessment of romosozumab: A review of scientific weight-of-evidence and findings in a rat lifetime pharmacology study.

Chouinard L, Felx M, Mellal N, Varela A, Mann P, Jolette J, Samadfam R, Smith SY, Locher K, Buntich S, Ominsky MS, Pyrah I, Boyce RW. Chouinard L, et al. Among authors: locher k. Regul Toxicol Pharmacol. 2016 Nov;81:212-222. doi: 10.1016/j.yrtph.2016.08.010. Epub 2016 Aug 26. Regul Toxicol Pharmacol. 2016. PMID: 27569204 Free article. Review.

3

Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys.

Ominsky MS, Boyd SK, Varela A, Jolette J, Felx M, Doyle N, Mellal N, Smith SY, Locher K, Buntich S, Pyrah I, Boyce RW. Ominsky MS, et al. Among authors: locher k. J Bone Miner Res. 2017 Apr;32(4):788-801. doi: 10.1002/jbmr.3036. Epub 2016 Dec 13. J Bone Miner Res. 2017. PMID: 27865001 Free article.

4

Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody.

Boyce RW, Brown D, Felx M, Mellal N, Locher K, Pyrah I, Ominsky MS, Taylor S. Boyce RW, et al. Among authors: locher k. Bone Rep. 2018 Mar 3;8:90-94. doi: 10.1016/j.bonr.2018.03.001. eCollection 2018 Jun. Bone Rep. 2018. PMID: 29955626 Free PMC article.

5

Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats.

Taylor S, Hu R, Pacheco E, Locher K, Pyrah I, Ominsky MS, Boyce RW. Taylor S, et al. Among authors: locher k. Bone Rep. 2018 Mar 15;8:95-103. doi: 10.1016/j.bonr.2018.03.002. eCollection 2018 Jun. Bone Rep. 2018. PMID: 29955627 Free PMC article.

6

Modulation of ABCG2 Transporter Activity by Ko143 Derivatives.

Yu Q, Dehghani-Ghahnaviyeh S, Rasouli A, Sadurni A, Kowal J, Bang-Soerensen R, Wen PC, Tinzl-Zechner M, Irobalieva RN, Ni D, Stahlberg H, Altmann KH, Tajkhorshid E, Locher KP. Yu Q, et al. Among authors: locher kp. ACS Chem Biol. 2024 Nov 15;19(11):2304-2313. doi: 10.1021/acschembio.4c00353. Epub 2024 Oct 24. ACS Chem Biol. 2024. PMID: 39445888 Free PMC article.

7

Investigation of suspected false positive norovirus results on a syndromic gastrointestinal multiplex molecular panel.

Caza M, Kuchinski K, Locher K, Gubbay J, Harms M, Goldfarb DM, Floyd R, Kenmuir E, Kalhor M, Charles M, Prystajecky N, Wilmer A. Caza M, et al. Among authors: locher k. J Clin Virol. 2024 Dec;175:105732. doi: 10.1016/j.jcv.2024.105732. Epub 2024 Sep 30. J Clin Virol. 2024. PMID: 39369683

8

Validation of an Automated, End-to-End Metagenomic Sequencing Assay for Agnostic Detection of Respiratory Viruses.

Gauthier NPG, Chan W, Locher K, Smailus D, Coope R, Charles M, Jassem A, Kopetzky J, Chorlton SD, Manges AR. Gauthier NPG, et al. Among authors: locher k. J Infect Dis. 2024 Dec 16;230(6):e1245-e1253. doi: 10.1093/infdis/jiae226. J Infect Dis. 2024. PMID: 38696336 Free PMC article.

9

Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB.

Lampson BL, Ramίrez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr. Lampson BL, et al. Among authors: locher kp. Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022. Cell. 2024. PMID: 38670073 Free article.

10

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP.

Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sørensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP. Liu H, et al. Among authors: locher kp. Nat Commun. 2024 Mar 20;15(1):2476. doi: 10.1038/s41467-024-46706-w. Nat Commun. 2024. PMID: 38509088 Free PMC article.

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