Smithgall TE - Search Results

1

In Vitro Evolution Reveals a Single Mutation as Sole Source of Src-Family Kinase C-Helix-out Inhibitor Resistance.

Patel RK, Patel YK, Smithgall TE. Patel RK, et al. Among authors: smithgall te. ACS Chem Biol. 2020 Aug 21;15(8):2175-2184. doi: 10.1021/acschembio.0c00373. Epub 2020 Jul 15. ACS Chem Biol. 2020. PMID: 32602694 Free PMC article.

2

SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.

Lerner EC, Smithgall TE. Lerner EC, et al. Among authors: smithgall te. Nat Struct Biol. 2002 May;9(5):365-9. doi: 10.1038/nsb782. Nat Struct Biol. 2002. PMID: 11976726

3

Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

Schreiner SJ, Schiavone AP, Smithgall TE. Schreiner SJ, et al. Among authors: smithgall te. J Biol Chem. 2002 Nov 22;277(47):45680-7. doi: 10.1074/jbc.M204255200. Epub 2002 Sep 19. J Biol Chem. 2002. PMID: 12244095 Free article.

4

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Wilson MB, et al. Among authors: smithgall te. Oncogene. 2002 Nov 21;21(53):8075-88. doi: 10.1038/sj.onc.1206008. Oncogene. 2002. PMID: 12444544

5

Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase.

Choi HJ, Smithgall TE. Choi HJ, et al. Among authors: smithgall te. J Mol Biol. 2004 Nov 5;343(5):1255-68. doi: 10.1016/j.jmb.2004.09.015. J Mol Biol. 2004. PMID: 15491611

6

Oligomerization is required for HIV-1 Nef-induced activation of the Src family protein-tyrosine kinase, Hck.

Ye H, Choi HJ, Poe J, Smithgall TE. Ye H, et al. Among authors: smithgall te. Biochemistry. 2004 Dec 21;43(50):15775-84. doi: 10.1021/bi048712f. Biochemistry. 2004. PMID: 15595833

7

SRC family kinase activity is required for murine embryonic stem cell growth and differentiation.

Meyn MA 3rd, Schreiner SJ, Dumitrescu TP, Nau GJ, Smithgall TE. Meyn MA 3rd, et al. Among authors: smithgall te. Mol Pharmacol. 2005 Nov;68(5):1320-30. doi: 10.1124/mol.104.010231. Epub 2005 Jun 28. Mol Pharmacol. 2005. PMID: 15985613

8

Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.

Meyn MA 3rd, Wilson MB, Abdi FA, Fahey N, Schiavone AP, Wu J, Hochrein JM, Engen JR, Smithgall TE. Meyn MA 3rd, et al. Among authors: smithgall te. J Biol Chem. 2006 Oct 13;281(41):30907-16. doi: 10.1074/jbc.M605902200. Epub 2006 Aug 15. J Biol Chem. 2006. PMID: 16912036 Free article.

9

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.

Pene-Dumitrescu T, Peterson LF, Donato NJ, Smithgall TE. Pene-Dumitrescu T, et al. Among authors: smithgall te. Oncogene. 2008 Nov 27;27(56):7055-69. doi: 10.1038/onc.2008.330. Epub 2008 Sep 15. Oncogene. 2008. PMID: 18794796 Free PMC article.

10

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages.

Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, Bahar I, Lazo JS, Day BW, Tsang M. Molina G, et al. Among authors: smithgall te. Nat Chem Biol. 2009 Sep;5(9):680-7. doi: 10.1038/nchembio.190. Epub 2009 Jul 5. Nat Chem Biol. 2009. PMID: 19578332 Free PMC article.

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