Li Y - Search Results

1

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

Li Y, Liu Z, Aglyamova G, Chen J, Chen H, Bhandari M, White MA, Rudenko G, Zhou J. Li Y, et al. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127300. doi: 10.1016/j.bmcl.2020.127300. Epub 2020 Jun 6. Bioorg Med Chem Lett. 2020. PMID: 32631520 Free PMC article.

2

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.

Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. Liu Z, et al. Among authors: li y. J Med Chem. 2020 May 28;63(10):5242-5256. doi: 10.1021/acs.jmedchem.0c00035. Epub 2020 Apr 22. J Med Chem. 2020. PMID: 32255647 Free PMC article.

3

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.

Li Y, Chen J, Bolinger AA, Chen H, Liu Z, Cong Y, Brasier AR, Pinchuk IV, Tian B, Zhou J. Li Y, et al. Inflamm Bowel Dis. 2021 Nov 15;27(Suppl 2):S38-S62. doi: 10.1093/ibd/izab190. Inflamm Bowel Dis. 2021. PMID: 34791293 Review.

4

Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.

Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G. Kumar A, et al. Among authors: li y. Nucleic Acids Res. 2022 Sep 9;50(16):9548-9567. doi: 10.1093/nar/gkac710. Nucleic Acids Res. 2022. PMID: 36039764 Free PMC article.

5

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Liu Z, et al. Among authors: li y. J Med Chem. 2022 Feb 10;65(3):2388-2408. doi: 10.1021/acs.jmedchem.1c01851. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982556 Free PMC article.

6

Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus.

Xu X, Mann M, Qiao D, Li Y, Zhou J, Brasier AR. Xu X, et al. Among authors: li y. Front Mol Biosci. 2021 Oct 26;8:728661. doi: 10.3389/fmolb.2021.728661. eCollection 2021. Front Mol Biosci. 2021. PMID: 34765643 Free PMC article.

7

Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation-Serial Fragmentation (PASEF) Mass Spectrometry.

Mann M, Roberts DS, Zhu Y, Li Y, Zhou J, Ge Y, Brasier AR. Mann M, et al. Among authors: li y. Viruses. 2021 Mar 11;13(3):454. doi: 10.3390/v13030454. Viruses. 2021. PMID: 33799525 Free PMC article.

8

[No title available]

[No authors listed] [No authors listed] PMID: 35556729

9

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis.

Bernau K, Skibba M, Leet JP, Furey S, Gehl C, Li Y, Zhou J, Sandbo N, Brasier AR. Bernau K, et al. Among authors: li y. Front Mol Med. 2022;2:842558. doi: 10.3389/fmmed.2022.842558. Epub 2022 Mar 15. Front Mol Med. 2022. PMID: 35782526 Free PMC article.

10

Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.

Ding X, Dai X, Long K, Peng C, Andreotti D, Bamborough P, Eatherton AJ, Edge C, Jandu KS, Nichols PL, Philps OJ, Stasi LP, Wan Z, Xiang JN, Dong K, Dossang P, Ho MH, Li Y, Mensah L, Guan X, Reith AD, Ren F. Ding X, et al. Among authors: li y. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4034-4038. doi: 10.1016/j.bmcl.2017.07.052. Epub 2017 Jul 21. Bioorg Med Chem Lett. 2017. PMID: 28774425

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