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SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. Mulay A, et al. Among authors: gomperts b. bioRxiv [Preprint]. 2020 Jun 29:2020.06.29.174623. doi: 10.1101/2020.06.29.174623. bioRxiv. 2020. Update in: Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j.celrep.2021.109055. PMID: 32637946 Free PMC article. Updated. Preprint.
Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response.
Purkayastha A, Sen C, Garcia G, Langerman J, Vijayaraj P, Shia DW, Meneses LK, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. Purkayastha A, et al. Among authors: gomperts bn. bioRxiv [Preprint]. 2020 Jul 29:2020.07.28.226092. doi: 10.1101/2020.07.28.226092. bioRxiv. 2020. Update in: Cell Stem Cell. 2020 Dec 3;27(6):869-875.e4. doi: 10.1016/j.stem.2020.11.010. PMID: 32766588 Free PMC article. Updated. Preprint.
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response.
Purkayastha A, Sen C, Garcia G Jr, Langerman J, Shia DW, Meneses LK, Vijayaraj P, Durra A, Koloff CR, Freund DR, Chi J, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. Purkayastha A, et al. Among authors: gomperts bn. Cell Stem Cell. 2020 Dec 3;27(6):869-875.e4. doi: 10.1016/j.stem.2020.11.010. Epub 2020 Nov 17. Cell Stem Cell. 2020. PMID: 33259798 Free PMC article.
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. Mullen PJ, et al. Among authors: gomperts bn. Nat Commun. 2021 Mar 25;12(1):1876. doi: 10.1038/s41467-021-22166-4. Nat Commun. 2021. PMID: 33767183 Free PMC article.
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.
Garcia G Jr, Sharma A, Ramaiah A, Sen C, Purkayastha A, Kohn DB, Parcells MS, Beck S, Kim H, Bakowski MA, Kirkpatrick MG, Riva L, Wolff KC, Han B, Yuen C, Ulmert D, Purbey PK, Scumpia P, Beutler N, Rogers TF, Chatterjee AK, Gabriel G, Bartenschlager R, Gomperts B, Svendsen CN, Betz UAK, Damoiseaux RD, Arumugaswami V. Garcia G Jr, et al. Among authors: gomperts b. Cell Rep. 2021 Apr 6;35(1):108940. doi: 10.1016/j.celrep.2021.108940. Epub 2021 Mar 18. Cell Rep. 2021. PMID: 33784499 Free PMC article.
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery.
Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. Mulay A, et al. Among authors: gomperts b. Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j.celrep.2021.109055. Epub 2021 Apr 13. Cell Rep. 2021. PMID: 33905739 Free PMC article.
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Carraro G, et al. Among authors: gomperts bn. Nat Med. 2021 May;27(5):806-814. doi: 10.1038/s41591-021-01332-7. Epub 2021 May 6. Nat Med. 2021. PMID: 33958799 Free PMC article.
Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response.
Garcia G Jr, Wang Y, Ignatius Irudayam J, Jeyachandran AV, Cario SC, Sen C, Li S, Li Y, Kumar A, Nielsen-Saines K, French SW, Shah PS, Morizono K, Gomperts B, Deb A, Ramaiah A, Arumugaswami V. Garcia G Jr, et al. Among authors: gomperts b. bioRxiv [Preprint]. 2022 Apr 8:2022.04.07.487520. doi: 10.1101/2022.04.07.487520. bioRxiv. 2022. Update in: PLoS Biol. 2022 Nov 8;20(11):e3001851. doi: 10.1371/journal.pbio.3001851. PMID: 35441167 Free PMC article. Updated. Preprint.
160 results