Leighton P - Search Results

1

Sleep is bi-directionally modified by amyloid beta oligomers.

Özcan GG, Lim S, Leighton P, Allison WT, Rihel J. Özcan GG, et al. Among authors: leighton p. Elife. 2020 Jul 14;9:e53995. doi: 10.7554/eLife.53995. Elife. 2020. PMID: 32660691 Free PMC article.

2

Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein.

Pollock NM, Leighton P, Neil G, Allison WT. Pollock NM, et al. Among authors: leighton p. Prion. 2021 Dec;15(1):70-81. doi: 10.1080/19336896.2021.1924557. Prion. 2021. PMID: 34139950 Free PMC article.

3

Amyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development.

Kaiser DM, Acharya M, Leighton PL, Wang H, Daude N, Wohlgemuth S, Shi B, Allison WT. Kaiser DM, et al. PLoS One. 2012;7(12):e51305. doi: 10.1371/journal.pone.0051305. Epub 2012 Dec 7. PLoS One. 2012. PMID: 23236467 Free PMC article.

4

Protein Misfolding in Prion and Prion-Like Diseases: Reconsidering a Required Role for Protein Loss-of-Function.

Leighton PL, Allison WT. Leighton PL, et al. J Alzheimers Dis. 2016 Jul 6;54(1):3-29. doi: 10.3233/JAD-160361. J Alzheimers Dis. 2016. PMID: 27392869 Review.

5

Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology.

Allison WT, DuVal MG, Nguyen-Phuoc K, Leighton PLA. Allison WT, et al. Int J Mol Sci. 2017 Oct 24;18(10):2223. doi: 10.3390/ijms18102223. Int J Mol Sci. 2017. PMID: 29064456 Free PMC article. Review.

6

An ancient conserved role for prion protein in learning and memory.

Leighton PLA, Nadolski NJ, Morrill A, Hamilton TJ, Allison WT. Leighton PLA, et al. Biol Open. 2018 Jan 22;7(1):bio025734. doi: 10.1242/bio.025734. Biol Open. 2018. PMID: 29358166 Free PMC article.

7

Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility.

Leighton PLA, Kanyo R, Neil GJ, Pollock NM, Allison WT. Leighton PLA, et al. J Biol Chem. 2018 Aug 10;293(32):12576-12592. doi: 10.1074/jbc.RA117.001171. Epub 2018 Jun 14. J Biol Chem. 2018. PMID: 29903907 Free PMC article.

8

Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein.

Kanyo R, Leighton PLA, Neil GJ, Locskai LF, Allison WT. Kanyo R, et al. Exp Neurol. 2020 Jun;328:113283. doi: 10.1016/j.expneurol.2020.113283. Epub 2020 Mar 9. Exp Neurol. 2020. PMID: 32165257

9

Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability.

Fleisch VC, Leighton PL, Wang H, Pillay LM, Ritzel RG, Bhinder G, Roy B, Tierney KB, Ali DW, Waskiewicz AJ, Allison WT. Fleisch VC, et al. Neurobiol Dis. 2013 Jul;55:11-25. doi: 10.1016/j.nbd.2013.03.007. Epub 2013 Mar 21. Neurobiol Dis. 2013. PMID: 23523635

10

Evaluating the mutagenic activity of targeted endonucleases containing a Sharkey FokI cleavage domain variant in zebrafish.

Pillay LM, Selland LG, Fleisch VC, Leighton PL, Cheng CS, Famulski JK, Ritzel RG, March LD, Wang H, Allison WT, Waskiewicz AJ. Pillay LM, et al. Zebrafish. 2013 Sep;10(3):353-64. doi: 10.1089/zeb.2012.0832. Epub 2013 Jun 19. Zebrafish. 2013. PMID: 23781947

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