Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering.
Plecitá-Hlavatá L, Engstová H, Alán L, Špaček T, Dlasková A, Smolková K, Špačková J, Tauber J, Strádalová V, Malínský J, Lessard M, Bewersdorf J, Ježek P.
Plecitá-Hlavatá L, et al. Among authors: engstova h.
FASEB J. 2016 May;30(5):1941-57. doi: 10.1096/fj.201500176. Epub 2016 Feb 17.
FASEB J. 2016.
PMID: 26887443
Metabolism is altered during hypoxia, and we therefore studied cristae morphology in HepG2 cells adapted to 5% oxygen for 72 h. Three dimensional (3D), super-resolution biplane fluorescence photoactivation localization microscopy with Eos-conjugated, ICS-located lactamase- …
Metabolism is altered during hypoxia, and we therefore studied cristae morphology in HepG2 cells adapted to 5% oxygen for 72 h. Three …