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A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
Jones HM, Tolsma J, Zhang Z, Jasper P, Luo H, Weber GL, Wright K, Bard J, Bell R, Messing D, Kelleher K, Piche-Nicholas N, Webster R. Jones HM, et al. Among authors: tolsma j. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):534-541. doi: 10.1002/psp4.12547. Epub 2020 Aug 17. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32697437 Free PMC article.
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
Kaddi CD, Niesner B, Baek R, Jasper P, Pappas J, Tolsma J, Li J, van Rijn Z, Tao M, Ortemann-Renon C, Easton R, Tan S, Puga AC, Schuchman EH, Barrett JS, Azer K. Kaddi CD, et al. Among authors: tolsma j. CPT Pharmacometrics Syst Pharmacol. 2018 Jul;7(7):442-452. doi: 10.1002/psp4.12304. Epub 2018 Jun 19. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29920993 Free PMC article.
A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
Abrams R, Kaddi CD, Tao M, Leiser RJ, Simoni G, Reali F, Tolsma J, Jasper P, van Rijn Z, Li J, Niesner B, Barrett JS, Marchetti L, Peterschmitt MJ, Azer K, Neves-Zaph S. Abrams R, et al. Among authors: tolsma j. CPT Pharmacometrics Syst Pharmacol. 2020 Jul;9(7):374-383. doi: 10.1002/psp4.12506. Epub 2020 Jun 19. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32558397 Free PMC article.
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1.
Betts A, Clark T, Jasper P, Tolsma J, van der Graaf PH, Graziani EI, Rosfjord E, Sung M, Ma D, Barletta F. Betts A, et al. Among authors: tolsma j. J Pharmacokinet Pharmacodyn. 2020 Oct;47(5):513-526. doi: 10.1007/s10928-020-09702-3. Epub 2020 Jul 24. J Pharmacokinet Pharmacodyn. 2020. PMID: 32710210 Free PMC article.
Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. Chien HC, et al. Among authors: tolsma j. Drug Metab Dispos. 2016 Mar;44(3):356-64. doi: 10.1124/dmd.115.066647. Epub 2015 Dec 23. Drug Metab Dispos. 2016. PMID: 26700958 Free PMC article.
30 results