Steinmetzer T - Search Results

1

Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity.

Bäuml CA, Paul George AA, Schmitz T, Sommerfeld P, Pietsch M, Podsiadlowski L, Steinmetzer T, Biswas A, Imhof D. Bäuml CA, et al. Among authors: steinmetzer t. Eur J Med Chem. 2020 Sep 1;201:112474. doi: 10.1016/j.ejmech.2020.112474. Epub 2020 May 23. Eur J Med Chem. 2020. PMID: 32698061

2

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Med Chem. 2010 Feb 11;53(3):1067-75. doi: 10.1021/jm9012455. J Med Chem. 2010. PMID: 20038105 Free PMC article.

3

Identification of the first low-molecular-weight inhibitors of matriptase-2.

Sisay MT, Steinmetzer T, Stirnberg M, Maurer E, Hammami M, Bajorath J, Gütschow M. Sisay MT, et al. Among authors: steinmetzer t. J Med Chem. 2010 Aug 12;53(15):5523-35. doi: 10.1021/jm100183e. J Med Chem. 2010. PMID: 20684597

4

Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.

Böhm M, Kühl T, Hardes K, Coch R, Arkona C, Schlott B, Steinmetzer T, Imhof D. Böhm M, et al. Among authors: steinmetzer t. ChemMedChem. 2012 Feb 6;7(2):326-33. doi: 10.1002/cmdc.201100405. Epub 2011 Dec 7. ChemMedChem. 2012. PMID: 22162181

5

A new strategy for the development of highly potent and selective plasmin inhibitors.

Saupe SM, Steinmetzer T. Saupe SM, et al. Among authors: steinmetzer t. J Med Chem. 2012 Feb 9;55(3):1171-80. doi: 10.1021/jm2011996. Epub 2012 Jan 25. J Med Chem. 2012. PMID: 22276953

6

Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.

Biela A, Sielaff F, Terwesten F, Heine A, Steinmetzer T, Klebe G. Biela A, et al. Among authors: steinmetzer t. J Med Chem. 2012 Jul 12;55(13):6094-110. doi: 10.1021/jm300337q. Epub 2012 Jun 25. J Med Chem. 2012. PMID: 22612268

7

Design, synthesis, and characterization of chromogenic substrates of coagulation factor XIIIa.

Hardes K, Becker GL, Hammamy MZ, Steinmetzer T. Hardes K, et al. Among authors: steinmetzer t. Anal Biochem. 2012 Sep 1;428(1):73-80. doi: 10.1016/j.ab.2012.05.023. Epub 2012 Jun 7. Anal Biochem. 2012. PMID: 22683584

8

Development of new cyclic plasmin inhibitors with excellent potency and selectivity.

Saupe SM, Leubner S, Betz M, Klebe G, Steinmetzer T. Saupe SM, et al. Among authors: steinmetzer t. J Med Chem. 2013 Feb 14;56(3):820-31. doi: 10.1021/jm3012917. Epub 2013 Jan 23. J Med Chem. 2013. PMID: 23294255

9

Synthesis and characterization of novel fluorogenic substrates of coagulation factor XIII-A.

Hardes K, Zouhir Hammamy M, Steinmetzer T. Hardes K, et al. Among authors: steinmetzer t. Anal Biochem. 2013 Nov 15;442(2):223-30. doi: 10.1016/j.ab.2013.07.043. Epub 2013 Aug 9. Anal Biochem. 2013. PMID: 23933241

10

Novel insights into structure and function of factor XIIIa-inhibitor tridegin.

Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D. Böhm M, et al. Among authors: steinmetzer t. J Med Chem. 2014 Dec 26;57(24):10355-65. doi: 10.1021/jm501058g. Epub 2014 Dec 5. J Med Chem. 2014. PMID: 25415134

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