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Structural basis of GPBAR activation and bile acid recognition.
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y. Yang F, et al. Among authors: jiang c. Nature. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. Epub 2020 Jul 22. Nature. 2020. PMID: 32698187
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.
Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu C, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C. Sun L, et al. Among authors: jiang c. Nat Med. 2018 Dec;24(12):1919-1929. doi: 10.1038/s41591-018-0222-4. Epub 2018 Nov 5. Nat Med. 2018. PMID: 30397356 Free PMC article.
Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.
Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, Wang L, Zhang Y, Liang X, Wang L, Gonzalez FJ, Patterson AD, Liu H, Mu L, Zhou Z, Zhao Y, Li R, Liu P, Zhong C, Pang Y, Jiang C, Qiao J. Qi X, et al. Among authors: jiang c. Nat Med. 2019 Aug;25(8):1225-1233. doi: 10.1038/s41591-019-0509-0. Epub 2019 Jul 22. Nat Med. 2019. PMID: 31332392 Free PMC article.
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P. Ma L, et al. Among authors: jiang c, jiang x. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2117054119. doi: 10.1073/pnas.2117054119. Epub 2022 Jul 15. Proc Natl Acad Sci U S A. 2022. PMID: 35858343 Free PMC article.
Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism.
Yan Y, Niu Z, Sun C, Li P, Shen S, Liu S, Wu Y, Yun C, Jiao T, Jia S, Li Y, Fang ZZ, Zhao L, Wang J, Xie C, Jiang C, Li Y, Feng X, Hu C, Jiang J, Ying H. Yan Y, et al. Among authors: jiang c, jiang j. Nat Commun. 2022 Oct 27;13(1):6408. doi: 10.1038/s41467-022-34258-w. Nat Commun. 2022. PMID: 36302774 Free PMC article.
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