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The indirubin derivative 6-bromoindirubin-3'-glycerol-oxime ether (6BIGOE) potently modulates inflammatory cytokine and prostaglandin release from human monocytes through GSK-3 interference.
Czapka A, König S, Pergola C, Grune C, Vougogiannopoulou K, Skaltsounis AL, Fischer D, Werz O. Czapka A, et al. Among authors: grune c. Biochem Pharmacol. 2020 Oct;180:114170. doi: 10.1016/j.bcp.2020.114170. Epub 2020 Jul 22. Biochem Pharmacol. 2020. PMID: 32710971
Drug delivery of 6-bromoindirubin-3'-glycerol-oxime ether employing poly(D,L-lactide-co-glycolide)-based nanoencapsulation techniques with sustainable solvents.
Czapka A, Grune C, Schädel P, Bachmann V, Scheuer K, Dirauf M, Weber C, Skaltsounis AL, Jandt KD, Schubert US, Fischer D, Werz O. Czapka A, et al. Among authors: grune c. J Nanobiotechnology. 2022 Jan 4;20(1):5. doi: 10.1186/s12951-021-01179-7. J Nanobiotechnology. 2022. PMID: 34983538 Free PMC article.