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Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer.
Groo AC, Hedir S, Since M, Brotin E, Weiswald LB, Paysant H, Nee G, Coolzaet M, Goux D, Delépée R, Freret T, Poulain L, Voisin-Chiret AS, Malzert-Fréon A. Groo AC, et al. Int J Pharm. 2020 Sep 25;587:119655. doi: 10.1016/j.ijpharm.2020.119655. Epub 2020 Jul 23. Int J Pharm. 2020. PMID: 32712252
First evidence that oligopyridines, α-helix foldamers, inhibit Mcl-1 and sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies.
Gloaguen C, Voisin-Chiret AS, Sopkova-de Oliveira Santos J, Fogha J, Gautier F, De Giorgi M, Burzicki G, Perato S, Pétigny-Lechartier C, Simonin-Le Jeune K, Brotin E, Goux D, N'Diaye M, Lambert B, Louis MH, Ligat L, Lopez F, Juin P, Bureau R, Rault S, Poulain L. Gloaguen C, et al. J Med Chem. 2015 Feb 26;58(4):1644-68. doi: 10.1021/jm500672y. Epub 2015 Feb 4. J Med Chem. 2015. PMID: 25585174
Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.
Hedir S, De Giorgi M, Fogha J, De Pascale M, Weiswald LB, Brotin E, Marekha B, Denoyelle C, Denis C, Suzanne P, Gautier F, Juin P, Ligat L, Lopez F, Carlier L, Legay R, Bureau R, Rault S, Poulain L, Oliveira Santos JS, Voisin-Chiret AS. Hedir S, et al. Eur J Med Chem. 2018 Nov 5;159:357-380. doi: 10.1016/j.ejmech.2018.10.003. Epub 2018 Oct 4. Eur J Med Chem. 2018. PMID: 30308410
Binding mode of Pyridoclax to myeloid cell leukemia-1 (Mcl-1) revealed by nuclear magnetic resonance spectroscopy, docking and molecular dynamics approaches.
Bourafai-Aziez A, Sebban M, Benabderrahmane M, Marekha B, Denis C, Paysant H, Weiswald LB, Carlier L, Bureau R, Coadou G, Ravault D, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Oulyadi H. Bourafai-Aziez A, et al. J Biomol Struct Dyn. 2020 Sep;38(14):4162-4178. doi: 10.1080/07391102.2019.1680434. Epub 2019 Oct 29. J Biomol Struct Dyn. 2020. PMID: 31612791
Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes.
De Pascale M, Iacopetta D, Since M, Corvaisier S, Vie V, Paboeuf G, Hennequin D, Perato S, De Giorgi M, Sinicropi MS, Sopkova-De Oliveira Santos J, Voisin-Chiret AS, Malzert-Freon A. De Pascale M, et al. ChemMedChem. 2020 Jan 7;15(1):136-154. doi: 10.1002/cmdc.201900542. Epub 2019 Nov 26. ChemMedChem. 2020. PMID: 31743599 Free article.
Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues.
Paysant H, Hedir S, Justaud F, Weiswald LB, El Dine AN, Soulieman A, Hachem A, Elie N, Brotin E, Denoyelle C, Bignon J, Roussi F, Jouanne M, Tasseau O, Roisnel T, Voisin-Chiret AS, Grée R, Levoin N, Poulain L. Paysant H, et al. Org Biomol Chem. 2021 Oct 27;19(41):8968-8987. doi: 10.1039/d1ob01521d. Org Biomol Chem. 2021. PMID: 34596646 Free article.
Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1.
Bourafai-Aziez A, Benabderrahmane M, Paysant H, Weiswald LB, Poulain L, Carlier L, Ravault D, Jouanne M, Coadou G, Oulyadi H, Voisin-Chiret AS, Sopková-de Oliveira Santos J, Sebban M. Bourafai-Aziez A, et al. Among authors: voisin chiret as. Drug Des Devel Ther. 2021 Dec 15;15:5035-5059. doi: 10.2147/DDDT.S323077. eCollection 2021. Drug Des Devel Ther. 2021. PMID: 34949914 Free PMC article.
Molecular glue degraders: exciting opportunities for novel drug discovery.
Lemaitre T, Cornu M, Schwalen F, Since M, Kieffer C, Voisin-Chiret AS. Lemaitre T, et al. Among authors: voisin chiret as. Expert Opin Drug Discov. 2024 Apr;19(4):433-449. doi: 10.1080/17460441.2024.2306845. Epub 2024 Jan 24. Expert Opin Drug Discov. 2024. PMID: 38240114 Review.
35 results