Hamilton JR - Search Results

1

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.

Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, Eckly A, Gachet C, Nesbitt WS, Thompson PE, Hamilton JR. Selvadurai MV, et al. Among authors: hamilton jr. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. doi: 10.1126/scitranslmed.aar8430. Sci Transl Med. 2020. PMID: 32718993

2

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Ono A, Westein E, Hsiao S, Nesbitt WS, Hamilton JR, Schoenwaelder SM, Jackson SP. Ono A, et al. Among authors: hamilton jr. Blood. 2008 Jul 1;112(1):90-9. doi: 10.1182/blood-2007-12-127001. Epub 2008 Feb 29. Blood. 2008. PMID: 18310501 Free article.

3

Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice.

Hamilton JR, Cornelissen I, Mountford JK, Coughlin SR. Hamilton JR, et al. Atherosclerosis. 2009 Aug;205(2):427-32. doi: 10.1016/j.atherosclerosis.2009.01.018. Epub 2009 Jan 23. Atherosclerosis. 2009. PMID: 19217621 Free PMC article.

4

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions.

Lee H, Sturgeon SA, Jackson SP, Hamilton JR. Lee H, et al. Among authors: hamilton jr. Thromb Haemost. 2012 Feb;107(2):328-37. doi: 10.1160/TH11-06-0418. Epub 2011 Dec 21. Thromb Haemost. 2012. PMID: 22187047

5

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice.

Lee H, Sturgeon SA, Mountford JK, Jackson SP, Hamilton JR. Lee H, et al. Among authors: hamilton jr. Br J Pharmacol. 2012 Aug;166(7):2188-97. doi: 10.1111/j.1476-5381.2012.01944.x. Br J Pharmacol. 2012. PMID: 22428607 Free PMC article.

6

Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.

Mountford SJ, Zheng Z, Sundaram K, Jennings IG, Hamilton JR, Thompson PE. Mountford SJ, et al. Among authors: hamilton jr. ACS Med Chem Lett. 2014 Sep 24;6(1):3-6. doi: 10.1021/ml500354e. eCollection 2015 Jan 8. ACS Med Chem Lett. 2014. PMID: 25589915 Free PMC article.

7

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP. Mountford JK, et al. Among authors: hamilton jr. Nat Commun. 2015 Mar 17;6:6535. doi: 10.1038/ncomms7535. Nat Commun. 2015. PMID: 25779105 Free article.

8

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.

French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR. French SL, et al. Among authors: hamilton jr. J Thromb Haemost. 2016 Aug;14(8):1642-54. doi: 10.1111/jth.13293. Epub 2016 Jun 22. J Thromb Haemost. 2016. PMID: 26878340 Free article.

9

Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability.

Petitjean C, Setiabakti NM, Mountford JK, Arthur JF, Ellis S, Hamilton JR. Petitjean C, et al. Among authors: hamilton jr. Platelets. 2016 Jul;27(5):402-9. doi: 10.3109/09537104.2016.1145202. Epub 2016 Mar 4. Platelets. 2016. PMID: 26943229 Free article.

10

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Zheng Z, Pinson JA, Mountford SJ, Orive S, Schoenwaelder SM, Shackleford D, Powell A, Nelson EM, Hamilton JR, Jackson SP, Jennings IG, Thompson PE. Zheng Z, et al. Among authors: hamilton jr. Eur J Med Chem. 2016 Oct 21;122:339-351. doi: 10.1016/j.ejmech.2016.06.010. Epub 2016 Jun 10. Eur J Med Chem. 2016. PMID: 27387421

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