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Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.
Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, Eckly A, Gachet C, Nesbitt WS, Thompson PE, Hamilton JR. Selvadurai MV, et al. Among authors: severin s. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. doi: 10.1126/scitranslmed.aar8430. Sci Transl Med. 2020. PMID: 32718993
Phosphoinositide 3-kinases in platelets, thrombosis and therapeutics.
Ribes A, Oprescu A, Viaud J, Hnia K, Chicanne G, Xuereb JM, Severin S, Gratacap MP, Payrastre B. Ribes A, et al. Among authors: severin s. Biochem J. 2020 Nov 27;477(22):4327-4342. doi: 10.1042/BCJ20190402. Biochem J. 2020. PMID: 33242335 Review.
Essential role of class II PI3K-C2α in platelet membrane morphology.
Valet C, Chicanne G, Severac C, Chaussade C, Whitehead MA, Cabou C, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S. Valet C, et al. Among authors: severin s. Blood. 2015 Aug 27;126(9):1128-37. doi: 10.1182/blood-2015-03-636670. Epub 2015 Jun 24. Blood. 2015. PMID: 26109204 Free article.
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.
Valet C, Levade M, Chicanne G, Bilanges B, Cabou C, Viaud J, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S. Valet C, et al. Among authors: severin s. Blood. 2017 Nov 2;130(18):2032-2042. doi: 10.1182/blood-2017-04-781641. Epub 2017 Sep 13. Blood. 2017. PMID: 28903944 Free PMC article.
The importance of blood platelet lipid signaling in thrombosis and in sepsis.
Vardon Bounes F, Mujalli A, Cenac C, Severin S, Le Faouder P, Chicanne G, Gaits-Iacovoni F, Minville V, Gratacap MP, Payrastre B. Vardon Bounes F, et al. Among authors: severin s. Adv Biol Regul. 2018 Jan;67:66-73. doi: 10.1016/j.jbior.2017.09.011. Epub 2017 Sep 29. Adv Biol Regul. 2018. PMID: 28993230 Review.
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
Léon C, Eckly A, Hechler B, Aleil B, Freund M, Ravanat C, Jourdain M, Nonne C, Weber J, Tiedt R, Gratacap MP, Severin S, Cazenave JP, Lanza F, Skoda R, Gachet C. Léon C, et al. Among authors: severin s. Blood. 2007 Nov 1;110(9):3183-91. doi: 10.1182/blood-2007-03-080184. Epub 2007 Jul 30. Blood. 2007. PMID: 17664350 Free article.
297 results