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p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, Löhr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dötsch V. Gebel J, et al. Nat Chem Biol. 2020 Oct;16(10):1078-1086. doi: 10.1038/s41589-020-0600-3. Epub 2020 Jul 27. Nat Chem Biol. 2020. PMID: 32719556
Analysis of the oligomeric state and transactivation potential of TAp73α.
Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V. Luh LM, et al. Among authors: gebel j. Cell Death Differ. 2013 Aug;20(8):1008-16. doi: 10.1038/cdd.2013.23. Epub 2013 Mar 29. Cell Death Differ. 2013. PMID: 23538419 Free PMC article.
Control mechanisms in germ cells mediated by p53 family proteins.
Gebel J, Tuppi M, Krauskopf K, Coutandin D, Pitzius S, Kehrloesser S, Osterburg C, Dötsch V. Gebel J, et al. J Cell Sci. 2017 Aug 9:jcs.204859. doi: 10.1242/jcs.204859. Online ahead of print. J Cell Sci. 2017. PMID: 28794013 Review.
Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.
Nemajerova A, Amelio I, Gebel J, Dötsch V, Melino G, Moll UM. Nemajerova A, et al. Among authors: gebel j. Cell Death Differ. 2018 Jan;25(1):144-153. doi: 10.1038/cdd.2017.178. Epub 2017 Oct 27. Cell Death Differ. 2018. PMID: 29077094 Free PMC article. Review.
Deletions and loss-of-function variants in TP63 associated with orofacial clefting.
Khandelwal KD, van den Boogaard MH, Mehrem SL, Gebel J, Fagerberg C, van Beusekom E, van Binsbergen E, Topaloglu O, Steehouwer M, Gilissen C, Ishorst N, van Rooij IALM, Roeleveld N, Christensen K, Schoenaers J, Bergé S, Murray JC, Hens G, Devriendt K, Ludwig KU, Mangold E, Hoischen A, Zhou H, Dötsch V, Carels CEL, van Bokhoven H. Khandelwal KD, et al. Among authors: gebel j. Eur J Hum Genet. 2019 Jul;27(7):1101-1112. doi: 10.1038/s41431-019-0370-0. Epub 2019 Mar 8. Eur J Hum Genet. 2019. PMID: 30850703 Free PMC article. Clinical Trial.
144 results