A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome.
Khazal FA, Holte MN, Bolon B, White TA, LeBrasseur N, Iii LJM.
Khazal FA, et al. Among authors: bolon b.
FASEB J. 2019 Dec;33(12):13189-13201. doi: 10.1096/fj.201802655RR. Epub 2019 Aug 30.
FASEB J. 2019.
PMID: 31469588
Free PMC article.
Remarkably, as has been shown for other mitochondrial diseases, chronic hypoxia offers substantial protection to mice from this condition after systemic SDH loss, allowing survival in the context of profoundly impaired oxidative metabolism.-Al Khazal, F., Holte, M. N., Bolon …
Remarkably, as has been shown for other mitochondrial diseases, chronic hypoxia offers substantial protection to mice from this condition af …