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Page 1
Engineered T cells directed at tumors with defined allelic loss.
Hamburger AE, DiAndreth B, Cui J, Daris ME, Munguia ML, Deshmukh K, Mock JY, Asuelime GE, Lim ED, Kreke MR, Tokatlian T, Kamb A. Hamburger AE, et al. Mol Immunol. 2020 Dec;128:298-310. doi: 10.1016/j.molimm.2020.09.012. Epub 2020 Oct 1. Mol Immunol. 2020. PMID: 33012527 Free article.
Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells.
Tokatlian T, Asuelime GE, Mock JY, DiAndreth B, Sharma S, Toledo Warshaviak D, Daris ME, Bolanos K, Luna BL, Naradikian MS, Deshmukh K, Hamburger AE, Kamb A. Tokatlian T, et al. Among authors: hamburger ae. J Immunother Cancer. 2022 Jan;10(1):e003826. doi: 10.1136/jitc-2021-003826. J Immunother Cancer. 2022. PMID: 35091455 Free PMC article.
HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen.
Mock JY, Winters A, Riley TP, Bruno R, Naradikian MS, Sharma S, Jette CA, Elshimali R, Gahrs C, Toledo-Warshaviak D, West AP Jr, Kamb A, Hamburger AE. Mock JY, et al. Among authors: hamburger ae. Mol Ther Oncolytics. 2022 Oct 4;27:157-166. doi: 10.1016/j.omto.2022.09.010. eCollection 2022 Dec 15. Mol Ther Oncolytics. 2022. PMID: 36381658 Free PMC article.
Monoclonal antibodies to B and T lymphocyte attenuator (BTLA) have no effect on in vitro B cell proliferation and act to inhibit in vitro T cell proliferation when presented in a cis, but not trans, format relative to the activating stimulus.
Zhang M, Howard K, Winters A, Steavenson S, Anderson S, Smelt S, Doellgast G, Sheelo C, Stevens J, Kim H, Hamburger A, Sein A, Caughey DJ, Lee F, Hsu H, Siu G, Byrne FR. Zhang M, et al. Clin Exp Immunol. 2011 Jan;163(1):77-87. doi: 10.1111/j.1365-2249.2010.04259.x. Epub 2010 Nov 16. Clin Exp Immunol. 2011. PMID: 21078085 Free PMC article.
Crystal structure of the S.cerevisiae exocyst component Exo70p.
Hamburger ZA, Hamburger AE, West AP Jr, Weis WI. Hamburger ZA, et al. Among authors: hamburger ae. J Mol Biol. 2006 Feb 10;356(1):9-21. doi: 10.1016/j.jmb.2005.09.099. Epub 2005 Nov 10. J Mol Biol. 2006. PMID: 16359701
18 results