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Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression.
Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, Arnold LA, Cook JM. Li G, et al. Among authors: cook jm. ARKIVOC. 2018;2018(4):158-182. doi: 10.24820/ark.5550190.p010.460. Epub 2018 Mar 11. ARKIVOC. 2018. PMID: 32774192 Free PMC article.
Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis.
Tiruveedhula VV, Witzigmann CM, Verma R, Kabir MS, Rott M, Schwan WR, Medina-Bielski S, Lane M, Close W, Polanowski RL, Sherman D, Monte A, Deschamps JR, Cook JM. Tiruveedhula VV, et al. Among authors: cook jm. Bioorg Med Chem. 2013 Dec 15;21(24):7830-40. doi: 10.1016/j.bmc.2013.10.011. Epub 2013 Oct 21. Bioorg Med Chem. 2013. PMID: 24200931 Free PMC article.
Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.
Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Obradović ALj, et al. Among authors: cook jm. Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25. Brain Res. 2014. PMID: 24472579 Free PMC article.
Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats.
Kovačević J, Timić T, Tiruveedhula VV, Batinić B, Namjoshi OA, Milić M, Joksimović S, Cook JM, Savić MM. Kovačević J, et al. Among authors: cook jm. Brain Res Bull. 2014 May;104:1-6. doi: 10.1016/j.brainresbull.2014.03.002. Epub 2014 Mar 30. Brain Res Bull. 2014. PMID: 24695241 Free PMC article.
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Sidhu PS, et al. Among authors: cook jm. ACS Med Chem Lett. 2014 Feb 13;5(2):199-204. doi: 10.1021/ml400462j. ACS Med Chem Lett. 2014. PMID: 24799995 Free PMC article.
626 results