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Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.
Mast FD, Navare AT, van der Sloot AM, Coulombe-Huntington J, Rout MP, Baliga NS, Kaushansky A, Chait BT, Aderem A, Rice CM, Sali A, Tyers M, Aitchison JD. Mast FD, et al. Among authors: kaushansky a. J Cell Biol. 2020 Oct 5;219(10):e202006159. doi: 10.1083/jcb.202006159. J Cell Biol. 2020. PMID: 32785687 Free PMC article.
Using machine learning to dissect host kinases required for Leishmania internalization and development.
Wei L, Barrie U, Aloisio GM, Khuong FTH, Arang N, Datta A, Kaushansky A, Wetzel DM. Wei L, et al. Among authors: kaushansky a. bioRxiv [Preprint]. 2024 Aug 4:2024.05.16.593986. doi: 10.1101/2024.05.16.593986. bioRxiv. 2024. Update in: Mol Biochem Parasitol. 2024 Aug 22;260:111651. doi: 10.1016/j.molbiopara.2024.111651. PMID: 38798624 Free PMC article. Updated. Preprint.
Liver stage malaria infection is controlled by host regulators of lipid peroxidation.
Kain HS, Glennon EKK, Vijayan K, Arang N, Douglass AN, Fortin CL, Zuck M, Lewis AJ, Whiteside SL, Dudgeon DR, Johnson JS, Aderem A, Stevens KR, Kaushansky A. Kain HS, et al. Among authors: kaushansky a. Cell Death Differ. 2020 Jan;27(1):44-54. doi: 10.1038/s41418-019-0338-1. Epub 2019 May 7. Cell Death Differ. 2020. PMID: 31065106 Free PMC article.
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.
Navare AT, Mast FD, Olivier JP, Bertomeu T, Neal M, Carpp LN, Kaushansky A, Coulombe-Huntington J, Tyers M, Aitchison JD. Navare AT, et al. Among authors: kaushansky a. bioRxiv [Preprint]. 2020 Nov 6;221(11):2020.10.12.336487. doi: 10.1101/2020.10.12.336487. bioRxiv. 2020. Update in: J Cell Biol. 2022 Nov 7;221(11):e202011050. doi: 10.1083/jcb.202011050. PMID: 33173868 Free PMC article. Updated. Preprint.
A systems-level gene regulatory network model for Plasmodium falciparum.
Neal ML, Wei L, Peterson E, Arrieta-Ortiz ML, Danziger SA, Baliga NS, Kaushansky A, Aitchison JD. Neal ML, et al. Among authors: kaushansky a. Nucleic Acids Res. 2021 May 21;49(9):4891-4906. doi: 10.1093/nar/gkaa1245. Nucleic Acids Res. 2021. PMID: 33450011 Free PMC article.
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.
Vijayan K, Arang N, Wei L, Morrison R, Geiger R, Parks KR, Lewis AJ, Mast FD, Douglass AN, Kain HS, Aitchison JD, Johnson JS, Aderem A, Kaushansky A. Vijayan K, et al. Among authors: kaushansky a. Cell Chem Biol. 2022 Sep 15;29(9):1419-1433.e5. doi: 10.1016/j.chembiol.2022.06.001. Epub 2022 Jun 22. Cell Chem Biol. 2022. PMID: 35738280 Free PMC article.
88 results