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Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials.
J Med Chem. 2020 Sep 10;63(17):9300-9315. doi: 10.1021/acs.jmedchem.0c00451. Epub 2020 Aug 11.
J Med Chem. 2020.
PMID: 32787140
Free PMC article.
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target.
Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma DC, Vázquez MJ, Colmenarejo G, Lafuente-Monasterio MJ, Leon ML, Godoi PHC, Elkins JM, Waters AP, Jamieson AG, Álvaro EF, Ranford-Cartwright LC, Marti M, Winzeler EA, Gamo FJ, Tobin AB.
Alam MM, et al. Among authors: mapesa k.
Science. 2019 Aug 30;365(6456):eaau1682. doi: 10.1126/science.aau1682.
Science. 2019.
PMID: 31467193
Free article.
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