Wu NC - Search Results

1

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity.

Thai E, Costa G, Weyrich A, Murugan R, Oyen D, Flores-Garcia Y, Prieto K, Bosch A, Valleriani A, Wu NC, Pholcharee T, Scally SW, Wilson IA, Wardemann H, Julien JP, Levashina EA. Thai E, et al. Among authors: wu nc. J Exp Med. 2020 Nov 2;217(11):e20200061. doi: 10.1084/jem.20200061. J Exp Med. 2020. PMID: 32790871 Free PMC article.

2

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.

Lee JH, Andrabi R, Su CY, Yasmeen A, Julien JP, Kong L, Wu NC, McBride R, Sok D, Pauthner M, Cottrell CA, Nieusma T, Blattner C, Paulson JC, Klasse PJ, Wilson IA, Burton DR, Ward AB. Lee JH, et al. Among authors: wu nc. Immunity. 2017 Apr 18;46(4):690-702. doi: 10.1016/j.immuni.2017.03.017. Immunity. 2017. PMID: 28423342 Free PMC article.

3

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity.

Wu NC, Grande G, Turner HL, Ward AB, Xie J, Lerner RA, Wilson IA. Wu NC, et al. Nat Commun. 2017 May 15;8:15371. doi: 10.1038/ncomms15371. Nat Commun. 2017. PMID: 28504265 Free PMC article.

4

Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin.

Wu NC, Xie J, Zheng T, Nycholat CM, Grande G, Paulson JC, Lerner RA, Wilson IA. Wu NC, et al. Cell Host Microbe. 2017 Jun 14;21(6):742-753.e8. doi: 10.1016/j.chom.2017.05.011. Cell Host Microbe. 2017. PMID: 28618270 Free PMC article.

5

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus.

Wu NC, Wilson IA. Wu NC, et al. J Mol Biol. 2017 Aug 18;429(17):2694-2709. doi: 10.1016/j.jmb.2017.06.015. Epub 2017 Jun 23. J Mol Biol. 2017. PMID: 28648617 Free PMC article. Review.

6

Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin.

Wright ZVF, Wu NC, Kadam RU, Wilson IA, Wolan DW. Wright ZVF, et al. Among authors: wu nc. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3744-3748. doi: 10.1016/j.bmcl.2017.06.074. Epub 2017 Jun 28. Bioorg Med Chem Lett. 2017. PMID: 28689973 Free PMC article.

7

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in V_H1-69 Antibody Orientation on the HA Stem.

Lang S, Xie J, Zhu X, Wu NC, Lerner RA, Wilson IA. Lang S, et al. Among authors: wu nc. Cell Rep. 2017 Sep 19;20(12):2935-2943. doi: 10.1016/j.celrep.2017.08.084. Cell Rep. 2017. PMID: 28930686 Free PMC article.

8

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.

Wu NC, Zost SJ, Thompson AJ, Oyen D, Nycholat CM, McBride R, Paulson JC, Hensley SE, Wilson IA. Wu NC, et al. PLoS Pathog. 2017 Oct 23;13(10):e1006682. doi: 10.1371/journal.ppat.1006682. eCollection 2017 Oct. PLoS Pathog. 2017. PMID: 29059230 Free PMC article.

9

Structural insights into the design of novel anti-influenza therapies.

Wu NC, Wilson IA. Wu NC, et al. Nat Struct Mol Biol. 2018 Feb;25(2):115-121. doi: 10.1038/s41594-018-0025-9. Epub 2018 Feb 2. Nat Struct Mol Biol. 2018. PMID: 29396418 Free PMC article. Review.

10

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.

Wu NC, Thompson AJ, Xie J, Lin CW, Nycholat CM, Zhu X, Lerner RA, Paulson JC, Wilson IA. Wu NC, et al. Nat Commun. 2018 Mar 28;9(1):1264. doi: 10.1038/s41467-018-03663-5. Nat Commun. 2018. PMID: 29593268 Free PMC article.

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