Pals DT - Search Results

1

Renin inhibitors containing psi[CH2O] pseudopeptide inserts.

TenBrink RE, Pals DT, Harris DW, Johnson GA. TenBrink RE, et al. Among authors: pals dt. J Med Chem. 1988 Mar;31(3):671-7. doi: 10.1021/jm00398a029. J Med Chem. 1988. PMID: 3279210

2

Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.

Thaisrivongs S, Pals DT, Harris DW, Kati WM, Turner SR. Thaisrivongs S, et al. Among authors: pals dt. J Med Chem. 1986 Oct;29(10):2088-93. doi: 10.1021/jm00160a049. J Med Chem. 1986. PMID: 3531518

3

alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.

Thaisrivongs S, Pals DT, Lawson JA, Turner SR, Harris DW. Thaisrivongs S, et al. Among authors: pals dt. J Med Chem. 1987 Mar;30(3):536-41. doi: 10.1021/jm00386a016. J Med Chem. 1987. PMID: 3546690

4

Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions.

Sawyer TK, Pals DT, Mao B, Staples DJ, de Vaux AE, Maggiora LL, Affholter JA, Kati W, Duchamp D, Hester JB, et al. Sawyer TK, et al. Among authors: pals dt. J Med Chem. 1988 Jan;31(1):18-30. doi: 10.1021/jm00396a006. J Med Chem. 1988. PMID: 3275777

5

Conformationally constrained renin inhibitory peptides: gamma-lactam-bridged dipeptide isostere as conformational restriction.

Thaisrivongs S, Pals DT, Turner SR, Kroll LT. Thaisrivongs S, et al. Among authors: pals dt. J Med Chem. 1988 Jul;31(7):1369-76. doi: 10.1021/jm00402a021. J Med Chem. 1988. PMID: 3290485

6

Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site.

Smith CW, Saneii HH, Sawyer TK, Pals DT, Scahill TA, Kamdar BV, Lawson JA. Smith CW, et al. Among authors: pals dt. J Med Chem. 1988 Jul;31(7):1377-82. doi: 10.1021/jm00402a022. J Med Chem. 1988. PMID: 3290486

7

An orally active inhibitor of renin.

Pals DT, Thaisrivongs S, Lawson JA, Kati WM, Turner SR, DeGraaf GL, Harris DW, Johnson GA. Pals DT, et al. Hypertension. 1986 Dec;8(12):1105-12. doi: 10.1161/01.hyp.8.12.1105. Hypertension. 1986. PMID: 3539793

8

Tetrahydro-2-benzoxepins: a novel family of hypotensives.

TenBrink RE, McCall JM, Pals DT, McCall RB, Orley J, Humphrey SJ, Wendling MG. TenBrink RE, et al. Among authors: pals dt. J Med Chem. 1981 Jan;24(1):64-7. doi: 10.1021/jm00133a014. J Med Chem. 1981. PMID: 7205878

9

Potent renin inhibitory peptides containing hydrophilic end groups.

Bundy GL, Pals DT, Lawson JA, Couch SJ, Lipton MF, Mauragis MA. Bundy GL, et al. Among authors: pals dt. J Med Chem. 1990 Aug;33(8):2276-83. doi: 10.1021/jm00170a036. J Med Chem. 1990. PMID: 2197413

10

Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys.

Thaisrivongs S, Pals DT, DuCharme DW, Turner SR, DeGraaf GL, Lawson JA, Couch SJ, Williams MV. Thaisrivongs S, et al. Among authors: pals dt. J Med Chem. 1991 Feb;34(2):633-42. doi: 10.1021/jm00106a026. J Med Chem. 1991. PMID: 1995887

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