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5,819 results

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Page 1
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls L, Park YJ, Stewart L, Diamond M, Veesler D, Baker D. Cao L, et al. Among authors: baker d. bioRxiv [Preprint]. 2020 Aug 3:2020.08.03.234914. doi: 10.1101/2020.08.03.234914. bioRxiv. 2020. Update in: Science. 2020 Oct 23;370(6515):426-431. doi: 10.1126/science.abd9909 PMID: 32793905 Free PMC article. Updated. Preprint.
Massively parallel de novo protein design for targeted therapeutics.
Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Chevalier A, et al. Among authors: baker d. Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27. Nature. 2017. PMID: 28953867 Free PMC article.
De novo design of potent and selective mimics of IL-2 and IL-15.
Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. Silva DA, et al. Among authors: baker d. Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9. Nature. 2019. PMID: 30626941 Free PMC article.
De novo design of modular and tunable allosteric biosensors.
Quijano-Rubio A, Yeh HW, Park J, Lee H, Langan RA, Boyken SE, Lajoie MJ, Cao L, Chow CM, Miranda MC, Wi J, Hong HJ, Stewart L, Oh BH, Baker D. Quijano-Rubio A, et al. Among authors: baker d. bioRxiv [Preprint]. 2020 Jul 20:2020.07.18.206946. doi: 10.1101/2020.07.18.206946. bioRxiv. 2020. Update in: Nature. 2021 Mar;591(7850):482-487. doi: 10.1038/s41586-021-03258-z PMID: 32743576 Free PMC article. Updated. Preprint.
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. Cao L, et al. Among authors: baker d. Science. 2020 Oct 23;370(6515):426-431. doi: 10.1126/science.abd9909. Epub 2020 Sep 9. Science. 2020. PMID: 32907861 Free PMC article.
Designed proteins assemble antibodies into modular nanocages.
Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D. Divine R, et al. Among authors: baker d. bioRxiv [Preprint]. 2020 Dec 1:2020.12.01.406611. doi: 10.1101/2020.12.01.406611. bioRxiv. 2020. Update in: Science. 2021 Apr 2;372(6537):eabd9994. doi: 10.1126/science.abd9994 PMID: 33299994 Free PMC article. Updated. Preprint.
F-domain valency determines outcome of signaling through the angiopoietin pathway.
Zhao YT, Fallas JA, Saini S, Ueda G, Somasundaram L, Zhou Z, Xavier I, Ehnes D, Xu C, Carter L, Wrenn S, Mathieu J, Sellers DL, Baker D, Ruohola-Baker H. Zhao YT, et al. Among authors: baker d. bioRxiv [Preprint]. 2020 Dec 24:2020.09.19.304188. doi: 10.1101/2020.09.19.304188. bioRxiv. 2020. Update in: EMBO Rep. 2021 Dec 6;22(12):e53471. doi: 10.15252/embr.202153471 PMID: 33501432 Free PMC article. Updated. Preprint.
5,819 results