Wiseman RL - Search Results

1

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts.

Kirak O, Ke E, Yang KY, Schwarz A, Plate L, Nham A, Abadejos JR, Valencia A, Wiseman RL, Lui KO, Ku M. Kirak O, et al. Among authors: wiseman rl. Int J Mol Sci. 2020 Aug 11;21(16):5743. doi: 10.3390/ijms21165743. Int J Mol Sci. 2020. PMID: 32796510 Free PMC article.

2

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain.

Cooley CB, Ryno LM, Plate L, Morgan GJ, Hulleman JD, Kelly JW, Wiseman RL. Cooley CB, et al. Among authors: wiseman rl. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13046-51. doi: 10.1073/pnas.1406050111. Epub 2014 Aug 25. Proc Natl Acad Sci U S A. 2014. PMID: 25157167 Free PMC article.

3

Modulating protein quality control.

Plate L, Paxman RJ, Wiseman RL, Kelly JW. Plate L, et al. Among authors: wiseman rl. Elife. 2016 Jul 20;5:e18431. doi: 10.7554/eLife.18431. Elife. 2016. PMID: 27435959 Free PMC article.

4

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy.

Plate L, Wiseman RL. Plate L, et al. Among authors: wiseman rl. Trends Cell Biol. 2017 Oct;27(10):722-737. doi: 10.1016/j.tcb.2017.05.006. Epub 2017 Jun 21. Trends Cell Biol. 2017. PMID: 28647092 Free PMC article. Review.

5

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL. Chen KC, et al. Among authors: wiseman rl. EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27. EMBO J. 2017. PMID: 28655754 Free PMC article.

6

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. Kroeger H, et al. Among authors: wiseman rl. Sci Signal. 2018 Feb 13;11(517):eaan5785. doi: 10.1126/scisignal.aan5785. Sci Signal. 2018. PMID: 29440509 Free PMC article.

7

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.

Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW. Paxman R, et al. Among authors: wiseman rl. Elife. 2018 Aug 7;7:e37168. doi: 10.7554/eLife.37168. Elife. 2018. PMID: 30084354 Free PMC article.

8

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.

Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Blackwood EA, et al. Among authors: wiseman rl. Nat Commun. 2019 Jan 14;10(1):187. doi: 10.1038/s41467-018-08129-2. Nat Commun. 2019. PMID: 30643122 Free PMC article.

9

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing.

Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Grandjean JMD, et al. Among authors: wiseman rl. ACS Chem Biol. 2019 Apr 19;14(4):784-795. doi: 10.1021/acschembio.9b00134. Epub 2019 Mar 13. ACS Chem Biol. 2019. PMID: 30821953 Free PMC article.

10

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein.

Plate L, Rius B, Nguyen B, Genereux JC, Kelly JW, Wiseman RL. Plate L, et al. Among authors: wiseman rl. Cell Chem Biol. 2019 Jul 18;26(7):913-925.e4. doi: 10.1016/j.chembiol.2019.04.001. Epub 2019 May 16. Cell Chem Biol. 2019. PMID: 31105062 Free PMC article.

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