Chen Z - Search Results

1

Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.

Zhao J, Chen Z, Kusnetzow AK, Nguyen J, Rico-Bautista E, Tan H, Betz SF, Struthers RS, Zhu Y. Zhao J, et al. Among authors: chen z. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127496. doi: 10.1016/j.bmcl.2020.127496. Epub 2020 Aug 14. Bioorg Med Chem Lett. 2020. PMID: 32805408

2

Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.

Li X, Hilgers M, Cunningham M, Chen Z, Trzoss M, Zhang J, Kohnen L, Lam T, Creighton C, G C K, Nelson K, Kwan B, Stidham M, Brown-Driver V, Shaw KJ, Finn J. Li X, et al. Among authors: chen z. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5171-6. doi: 10.1016/j.bmcl.2011.07.059. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21831637

3

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Nelson K, Brown-Driver V, Castellano A, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Finn J, Tari LW. Trzoss M, et al. Among authors: chen z. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1537-43. doi: 10.1016/j.bmcl.2012.11.073. Epub 2012 Dec 8. Bioorg Med Chem Lett. 2013. PMID: 23294697

4

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Tari LW, Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Nix J, Finn J. Tari LW, et al. Among authors: chen z. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1529-36. doi: 10.1016/j.bmcl.2012.11.032. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23352267

5

Synthesis and cytotoxic activities of 1-benzylidine substituted beta-carboline derivatives.

Cao R, Yi W, Wu Q, Guan X, Feng M, Ma C, Chen Z, Song H, Peng W. Cao R, et al. Among authors: chen z. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6558-61. doi: 10.1016/j.bmcl.2008.10.043. Epub 2008 Oct 14. Bioorg Med Chem Lett. 2008. PMID: 18952426

6

Synthesis and evaluation of 5-benzylidene(thio)barbiturate-beta-D-glycosides as mushroom tyrosinase inhibitors.

Yan Q, Cao R, Yi W, Yu L, Chen Z, Ma L, Song H. Yan Q, et al. Among authors: chen z. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4055-8. doi: 10.1016/j.bmcl.2009.06.018. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19564107

7

Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors.

Chen Z, Cai D, Mou D, Yan Q, Sun Y, Pan W, Wan Y, Song H, Yi W. Chen Z, et al. Bioorg Med Chem. 2014 Jul 1;22(13):3279-84. doi: 10.1016/j.bmc.2014.04.060. Epub 2014 May 15. Bioorg Med Chem. 2014. PMID: 24857777

8

Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.

Yu L, Cao R, Yi W, Yan Q, Chen Z, Ma L, Peng W, Song H. Yu L, et al. Among authors: chen z. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3254-8. doi: 10.1016/j.bmcl.2010.04.059. Epub 2010 Apr 18. Bioorg Med Chem Lett. 2010. PMID: 20452769

9

Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity.

Chen Z, Cao R, Shi B, Yi W, Yu L, Song H, Ren Z, Peng W. Chen Z, et al. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3876-9. doi: 10.1016/j.bmcl.2010.05.034. Epub 2010 May 15. Bioorg Med Chem Lett. 2010. PMID: 20627721

10

Study on the design, synthesis and structure-activity relationships of new thiosemicarbazone compounds as tyrosinase inhibitors.

Song S, You A, Chen Z, Zhu G, Wen H, Song H, Yi W. Song S, et al. Among authors: chen z. Eur J Med Chem. 2017 Oct 20;139:815-825. doi: 10.1016/j.ejmech.2017.08.033. Epub 2017 Aug 18. Eur J Med Chem. 2017. PMID: 28865277

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