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T-cells produce acidic niches in lymph nodes to suppress their own effector functions.
Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ. Wu H, et al. Nat Commun. 2020 Aug 17;11(1):4113. doi: 10.1038/s41467-020-17756-7. Nat Commun. 2020. PMID: 32807791 Free PMC article.
Reduction of metastasis using a non-volatile buffer.
Ibrahim Hashim A, Cornnell HH, Coelho Ribeiro Mde L, Abrahams D, Cunningham J, Lloyd M, Martinez GV, Gatenby RA, Gillies RJ. Ibrahim Hashim A, et al. Clin Exp Metastasis. 2011 Dec;28(8):841-9. doi: 10.1007/s10585-011-9415-7. Epub 2011 Aug 23. Clin Exp Metastasis. 2011. PMID: 21861189 Free PMC article.
Systemic buffers inhibit carcinogenesis in TRAMP mice.
Ibrahim-Hashim A, Cornnell HH, Abrahams D, Lloyd M, Bui M, Gillies RJ, Gatenby RA. Ibrahim-Hashim A, et al. J Urol. 2012 Aug;188(2):624-31. doi: 10.1016/j.juro.2012.03.113. Epub 2012 Jun 15. J Urol. 2012. PMID: 22704445 Free PMC article.
Acidity generated by the tumor microenvironment drives local invasion.
Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Estrella V, et al. Cancer Res. 2013 Mar 1;73(5):1524-35. doi: 10.1158/0008-5472.CAN-12-2796. Epub 2013 Jan 3. Cancer Res. 2013. PMID: 23288510 Free PMC article.
Buffer Therapy for Cancer.
Ribeiro MD, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Ibrahim-Hashim A, Gillies RJ. Ribeiro MD, et al. J Nutr Food Sci. 2012 Aug 15;2:6. J Nutr Food Sci. 2012. PMID: 24371544 Free PMC article.
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy.
Pilon-Thomas S, Kodumudi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mulé JJ, Ibrahim-Hashim A, Gillies RJ. Pilon-Thomas S, et al. Cancer Res. 2016 Mar 15;76(6):1381-90. doi: 10.1158/0008-5472.CAN-15-1743. Epub 2015 Dec 30. Cancer Res. 2016. PMID: 26719539 Free PMC article.
32 results