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T-cells produce acidic niches in lymph nodes to suppress their own effector functions.
Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim-Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ. Wu H, et al. Among authors: swietach p. Nat Commun. 2020 Aug 17;11(1):4113. doi: 10.1038/s41467-020-17756-7. Nat Commun. 2020. PMID: 32807791 Free PMC article.
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P. Wilson AD, et al. Among authors: swietach p. Cardiovasc Res. 2022 Nov 10;118(14):2946-2959. doi: 10.1093/cvr/cvab364. Cardiovasc Res. 2022. PMID: 34897412 Free PMC article.
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P. Hulikova A, et al. Among authors: swietach p. Basic Res Cardiol. 2022 Mar 31;117(1):17. doi: 10.1007/s00395-022-00924-9. Basic Res Cardiol. 2022. PMID: 35357563 Free PMC article.
Proton export upregulates aerobic glycolysis.
Russell S, Xu L, Kam Y, Abrahams D, Ordway B, Lopez AS, Bui MM, Johnson J, Epstein T, Ruiz E, Lloyd MC, Swietach P, Verduzco D, Wojtkowiak J, Gillies RJ. Russell S, et al. Among authors: swietach p. BMC Biol. 2022 Jul 15;20(1):163. doi: 10.1186/s12915-022-01340-0. BMC Biol. 2022. PMID: 35840963 Free PMC article.
107 results